Pilot Study on Gut Microbiota Profile in Indian Children with Type 1 Diabetes.

Background: Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM).

Objectives: To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control.

Methodology: Faecal samples of 29 children with T1DM were collected and faecal microbial DNA was extracted and subjected to 16S rRNA (ribosomal RNA) sequencing and further analysis.

A comparative study of the gut microbiome in Indian children with type 1 diabetes and healthy controls.

Introduction: Type 1 diabetes mellitus (T1DM) occurs in genetically susceptible individuals due to certain environmental triggers causing destruction of insulin secreting beta cells. One of the environmental triggers studied recently in the pathogenesis and progression of T1DM is the role of gut microbiome.

Objectives: (1) To compare the gut microbiome profile of T1DM children with healthy age, gender, and body mass index (BMI) matched controls.