Characterization of four structurally diverse inhibitors of SUR2-containing K channels.

Vascular smooth muscle ATP-sensitive potassium (K) channels play critical roles in modulating vascular tone and thus represent important drug targets for diverse cardiovascular pathologies. Despite extensive research efforts spanning several decades, the search for selective inhibitors that can discriminate between vascular K (i.e.

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Mouse Model of Dravet Syndrome.

Cannabidiol has been approved for the treatment of drug-resistant childhood epilepsies including Dravet syndrome (DS). Although the mechanism of anticonvulsant action of cannabidiol is unknown, emerging data suggests involvement of the transient receptor potential cation channel subfamily V member 1 (Trpv1). Pharmacological and genetic studies in conventional seizure models suggest Trpv1 is a novel anticonvulsant target.