Correction: Selective recognition of DNA defects by cyclometalated Ir(iii) complexes.

Correction for 'Selective recognition of DNA defects by cyclometalated Ir(iii) complexes' by David Paul Elisa Dayanidhi et al., Dalton Trans., 2019, 48, 13536-13540, DOI: .

Switch-on effect on conformation-specific arylamine-DNA adduct by cyclometalated Ir(III) complexes.

Arylamines are known to form covalent-DNA adducts upon metabolic activation. These covalent adducts adopt different conformational attributes, viz., major groove (B), stacked (S), and minor groove (W), and lead to different types of mutations.

Selective Recognition of Conformation-Specific Arylamine-DNA Adduct in Frameshift Model by [Ru(phen)(dppz)].

Arylamine modification of guanine base at the G position in the I sequence (-GGCGCC-) causes a frameshift mutation. Polymerase and F NMR studies have shown that the next flanking base at the 3' position to the G adduct modulates the mutational outcome because of its different conformations. Here, we have studied the interaction of the 16-mer I sequence (5'-CTCTCGGCCXATCAC-3') (G = -acetyl-2-aminofluorene (AAF)-dG and X is either C or T) with [Ru(phen)(dppz)] (phen = 1,10-phenanthroline and dppz = dipyrido[3,2-:2',3'-]phenazine).

Selective recognition of DNA defects by cyclometalated Ir(iii) complexes.

Selective detection of DNA defects is an attractive approach for early detection of various tumors and diseases. Ru(ii), Rh(iii) and hybrid complexes have been reported in this regard. Here, we present three heteroleptic cyclometalated Ir(iii) complexes [Ir(phpy)2(imiphen)]+(Ir-1), [Ir(phpy)2(furphen)]+(Ir-2) and [Ir(phpy)2(faqphen)]+(Ir-3) where imiphen: 2-(1H-imidazol-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline; furphen: 2-(furan-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline and faqphen: 2-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)anthracene-9,10-dione have been synthesized and characterized by analytical techniques.

Photocrosslinking of collagen using Ru(II)-polypyridyl complex functionalized gold nanoparticles.

Collagen, an extracellular matrix protein, has been used for diverse biological applications due to its clinically safe in nature and for the development of various biomedical devices. As the ECM protein is prone to degradation process, it is necessary to stabilize the collagen. In the present study, we have carried out the stabilization of collagen using newly synthesized gold nanoparticles conjugated with Ru(II) complexes (NCs) possessing different ligand environment.

Elastic compliance of fibrillar assemblies in type I collagen.

Fibrillary assemblies of Type I collagen find important applications in tissue engineering and as matrices for biophysical studies. The mechanical and structural properties of these structures are governed by factors such as protein concentration, temperature, pH and ionic strength. This study reports on an impedance based analysis of the elastic compliance of fibrillary assemblies of Type I collagen using quartz crystal microbalance with dissipation (QCM-D) at a fundamental frequency of 5 MHz and overtones (n = 3,5,7,9,11).

Investigation of nuclease, proteolytic and antiproliferative effects of copper(II) complexes of thiophenylmethanamine derivatives.

Four coordinate copper(II) complexes 1, 2 and 3 of ligands based on thiophenemethylamine containing imidazole, benzimidazole and pyridine moiety have been synthesized and characterized. Complex 1 has also been crystallographically characterized. The three complexes bind to DNA non-intercalatively, though partial intercalation in the case of complex 2 cannot be ruled out.

Structurally modified 1,10-phenanthroline based fluorophores for specific sensing of Ni2+ and Cu2+ ions.

We report two fluorophores with open coordination sites for specific sensing of Ni(2+) and Cu(2+) ions via a simple synthetic route. The fluorescence activity was completely quenched on coordination of the metal ions with the phenanthroline ring present in the fluorophore as is clearly evident from the photophysical studies.

Synthesis, characterization and binding studies of chromium(III) complex containing an intercalating ligand with DNA.

A chromium(III) complex [Cr(DPPZ)(2)Cl(2)](+), where DPPZ is a planar bidentate ligand with an extended aromatic system, has been found to bind strongly to CT DNA with an apparent binding constant of (1.8+/-0.5)x10(7) M(-1).

Photooxidation of DNA by a cobalt(II) tridentate complex.

[Co(bzimpy)(2)], where bzimpy is 2,6-bis(benzimidazol-2-yl)pyridine was synthesized and characterized by ESI-MS (electrospray ionization mass spectrometry), UV-visible and fluorescence spectra. Absorption titration and thermal denaturation experiments indicate that the complex binds to DNA with moderate strength. Viscosity measurement shows that the mode of binding could be surface binding.

Oxidative cleavage of DNA by tridentate copper (II) complex.

Copper (II) complex 1 having planar tridentate ligand, bzimpy, where bzimpy is 2,6-bis(benzimidazo-2-yl) pyridine was synthesized and characterized by UV-visible, FAB (fast atom bombardment) mass and infrared spectroscopy. From absorption titration data, the binding constant of Cu(II) with DNA was calculated to be (1.8+/-0.

Synthesis, characterization and DNA binding studies of a ruthenium(II) complex.

[Ru(bzimpy)(2)]Cl(2), where bzimpy is 2,6-bis(benzimidazol-2-yl) pyridine was synthesized and characterized by ESI-MS, UV-Visible, (1)H NMR and fluorescence spectra. Absorption titration and thermal denaturation experiments indicate that the complex binds to DNA with moderate strength. Viscosity measurement shows that the mode of binding could be surface binding.