Challenges for dental care of the paediatric patient born with cleft lip and/or palate.

This paper forms part of a series on the management of patients with cleft lip and/or palate (CLP). Children with CLP have a higher incidence of dental caries and dental anomalies. This paper explains the important roles of both the general dental practitioner and specialist paediatric dentist on the cleft team in managing these children alongside the multidisciplinary team.

Impact of Tourette's syndrome tics on healing following dental trauma.

The following case report outlines the impact of motor tics linked to Tourette's syndrome on dental development and healing following a dental injury to a maxillary central incisor. Emergency care and splinting of a mobile extruded maxillary left central incisor tooth was carried out at the local dentist on the same day as the dental trauma. A subsequent referral was made to the paediatric dental department for continued mobility of the maxillary central incisor on splint removal approximately 2 weeks later.

Hybrid Silica-Coated PLGA Nanoparticles for Enhanced Enzyme-Based Therapeutics.

Some cancer cells rely heavily on non-essential biomolecules for survival, growth, and proliferation. Enzyme based therapeutics can eliminate these biomolecules, thus specifically targeting neoplastic cells; however, enzyme therapeutics are susceptible to immune clearance, exhibit short half-lives, and require frequent administration. Encapsulation of therapeutic cargo within biocompatible and biodegradable poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) is a strategy for controlled release.

Contactless monitoring of respiratory rate (RR) and heart rate (HR) in non-acuity settings: a clinical validity study.

Objective: Patient monitoring in general wards primarily involves intermittent observation of temperature, heart rate (HR), respiratory rate (RR) and blood pressure performed by the nursing staff. Several hours can lapse between such measurements, and the patient may go unobserved. Despite the growing widespread use of sensors to monitor vital signs and physical activities of healthy individuals, most acutely ill hospitalised patients remain unmonitored, leaving them at an increased risk.

Evaluation and Mitigation of Racial Bias in Clinical Machine Learning Models: Scoping Review.

Background: Racial bias is a key concern regarding the development, validation, and implementation of machine learning (ML) models in clinical settings. Despite the potential of bias to propagate health disparities, racial bias in clinical ML has yet to be thoroughly examined and best practices for bias mitigation remain unclear.

Objective: Our objective was to perform a scoping review to characterize the methods by which the racial bias of ML has been assessed and describe strategies that may be used to enhance algorithmic fairness in clinical ML.

Utilizing Teledentistry to Manage Cleft Lip and Palate Patients in an Outpatient Setting.

Background: As a result of the current global pandemic, the dental profession has utilized teledentistry to reduce footfall in the hospitals and clinics where possible. Pediatric dental consultants form a vital part of a multidisciplinary team and regularly monitor the dental growth and development of patients with cleft lip and palate.

Objective: To assess the effectiveness of the service provided by pediatric dental consultants in the South Thames Cleft Service at Evelina Children's Hospital during the COVID-19 pandemic through virtual clinics.

Systematic review protocol to assess artificial intelligence diagnostic accuracy performance in detecting acute ischaemic stroke and large-vessel occlusions on CT and MR medical imaging.

Introduction: The use of artificial intelligence (AI) to support the diagnosis of acute ischaemic stroke (AIS) could improve patient outcomes and facilitate accurate tissue and vessel assessment. However, the evidence in published AI studies is inadequate and difficult to interpret which reduces the accountability of the diagnostic results in clinical settings. This study protocol describes a rigorous systematic review of the accuracy of AI in the diagnosis of AIS and detection of large-vessel occlusions (LVOs).

Clefts and Dental General Anesthesia: The South Thames Experience.

Background: Children with clefts have high dental needs and often require a dental general anesthesia (DGA) for the management of their dentition.

Objective: To assess the number of children with clefts requiring a pediatric dental consultant led DGA in the South Thames Cleft Service over a 3-year period.

Design: Data were collected retrospectively over a 36-month period.

Feasibility study of a force-sensing resistor device for landmark detection for neuraxial procedures and anesthesiologists' impact on device improvement.

The standard of care for neuraxial procedures is landmark palpation to determine the site of placement. This research study aimed to test the primary feasibility of VerTouch™, a force-sensing resistor device, to identify landmarks for the initiation of neuraxial procedures. Patients were recruited at the time of labour epidural, or when consenting for spinal anaesthesia for caesarean delivery at a single centre.

Effect of Quantification of Blood Loss on Activation of a Postpartum Hemorrhage Protocol and Use of Resources.

Objective: To determine if quantification of blood loss (QBL) would result in fewer activations of postpartum hemorrhage (PPH) protocols than visual estimation of blood loss (EBL) after cesarean birth and to track the use of related resources.

Design: Prospective observational trial.

Setting: A tertiary academic medical center in the midwestern United States.

The dental health of cleft patients attending the 18-month-old clinic at a specialised cleft centre.

Background Cleft lip and/or palate (CLP) patients are at high risk of developing dental caries and show a greater prevalence of dental defects.Aims To establish if CLP patients who attended the 18-month clinic had local dentists, were complying with oral hygiene instruction and had stopped bottle-feeding as per guidelines.Design Data were collected retrospectively over a 24-month period in which a total of 62 records were assessed.

An audit and service evaluation of the use of cone beam computed tomography (CBCT) in a paediatric dentistry department.

Objectives: CBCT exposes the paediatric patient to a higher X-ray dose and risk than normal dental radiographs. This study has two components: an audit and service evaluation. The audit aims to assess whether the use of CBCT in a Paediatric Dentistry department at a London hospital complies with European guidelines (SEDENTEXCT).

Acoustic Microcannons: Toward Advanced Microballistics.

Acoustically triggered microcannons, capable of loading and firing nanobullets (Nbs), are presented as powerful microballistic tools. Hollow conically shaped microcannon structures have been synthesized electrochemically and fully loaded with nanobullets made of silica or fluorescent microspheres, and perfluorocarbon emulsions, embedded in a gel matrix stabilizer. Application of a focused ultrasound pulse leads to the spontaneous vaporization of the perfluorocarbon emulsions within the microcannon and results in the rapid ejection of the nanobullets.

Controlling the self-assembly of magnetic nanoparticles by competing dipolar and isotropic particle interactions.

Control over the self-assembly of magnetic nanoparticles (MNP) into superstructures due to different types of coupling is of interest in the development of "bottom-up" fabrication schemes. Here we realize a simple strategy for the systematic variation of particle interaction potential in magnetic nanoparticles. This is achieved by varying the effective surface potential by means of a co-surfactant introduced in the course of the synthesis process.

Pre-clinical analysis of changes in intra-cellular biochemistry of glioblastoma multiforme (GBM) cells due to c-Myc silencing.

Glioblastoma Multiforme (GBM) is an aggressive form of brain Tumor that has few cures. In this study, we analyze the anti-proliferative effects of a new molecule JQ1 against GBMs induced in Wistar Rats. JQ1 is essentially a Myc inhibitor.

Simplified basic periodontal examination (BPE) in children and adolescents: a guide for general dental practitioners.

Unlabelled: Dental plaque-induced periodontal diseases are common in children and adults. Guidelines were previously not available for the periodontal screening of under 18s. However, new guidelines have been introduced by the British Society of Periodontology and the British Society of Paediatric Dentistry which set out recommendations for the periodontal screening and management of under 18s in primary dental care.

Amelogenesis imperfecta associated with dental follicular-like hamartomas and generalised gingival enlargement.

Background: Amelogenesis imperfecta (AI) is an inherited disorder characterised by generalised defects of dental enamel, but has been associated with other dental and medical conditions. It affects the appearance and structure of teeth, both in the primary and secondary dentition. AI in the presence of dental follicular hamartomas and gingival hyperplasia is rare and the management presents several challenges to the clinician.

Antimicrobial properties of dentine bonding agents determined using in vitro and ex vivo methods.

Aims: To determine the antimicrobial properties of a selection of dentine bonding agents [DBAs] using the disc diffusion and direct contact methods and an ex vivo method using extracted carious permanent molar teeth.

Methods: DBAs (n=15) were tested using Streptococcus mutans UA159 in disc diffusion and direct contact methods. In the ex vivo study 6 DBAs were selected and pre- and post-treatment samples of carious dentine (n< or =12) were taken.

An overview of the dens invaginatus with case examples.

Dens invaginatus is an uncommon dental anomaly in which there is a deepening of the cingulum with infolding of the enamel and dentine. The severity varies, from mild extension into the pulp cavity, to extreme forms in which the invagination extends through the root, resulting in a second opening at or near the apex, and complex morphology. The following cases report on the different management approaches to dens invaginatus and illustrate the difficulties encountered in managing such cases.

Copper(II) Complexes with Unusual Axial Phenolate Coordination as Structural Models for the Active Site in Galactose Oxidase: X-ray Crystal Structures and Spectral and Redox Properties of [Cu(bpnp)X] Complexes.

The crystal structures of [Cu(bpnp)(SCN)].NH(4)SCN (1), [Cu(bpnp)(CH(3)COO)].CH(3)OH.

Cascaded optical parametric oscillations.

We have observed the spectral and temporal characteristics of a 1.064-mm pumped, continuously tunable optical parametric oscillator (OPO) using a periodically poled lithium niobate nonlinear crystal. An efficient secondary OPO pumped by the resonant signal of the primary OPO was observed.