The interaction of glycogen nanoparticles with human blood.

Glycogen, a naturally sourced highly branched polysaccharide nanoparticle, has been receiving attention in the field of nanomedicine due to its inherent non-toxicity and biodegradability. However, often in the literature glycogen nanoparticles (NPs) are used that come from different commercial sources (animals and tissues), which have significantly different sizes, molecular weights, and protein content, meaning a comprehensive overview of the interactions of these differently-sourced NPs with the human immune system is missing. Herein, we investigated coagulation, immune cell association and inflammation responses triggered by source-dependent interactions of glycogen NPs in human blood, utilising four types of commercially available glycogen: phytoglycogen (PG) isolated from sweet corn kernels, oyster glycogen (OG), rabbit liver glycogen (RLG), and bovine liver glycogen (BLG).