Publications by authors named "Vaibhav Chadha"

Anti-thymocyte globulin (ATG) forms an essential component of conditioning in hematopoietic stem cell transplantation (HSCT). Due to the shift of donor preference to alternate donors, reliance on rabbit-ATG (rATG) has increased. Two different forms of rATG (Thymoglobuline and Grafalon) are available for clinical use but data to support the use of one over the other is sparse.

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Article Synopsis
  • Ghosal hematodiaphyseal dysplasia (GHDD) is a rare genetic disorder affecting bone development, characterized by issues like diaphyseal dysplasia of long bones and anemia that responds to steroids, caused by mutations in the TBXAS1 gene.
  • Two cases are presented: a 3-year-old boy with pallor and ecchymosis diagnosed with GHDD due to bicytopenia and bone marrow fibrosis, and a 20-month-old girl with symptoms including bloody stools and anemia, confirmed through genetic testing.
  • Early diagnosis and treatment with steroids can significantly improve patient outcomes, reducing transfusion needs and preventing further bone damage, which contributes to better growth
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Sirolimus (mammalian target of rapamycin inhibitor) is a potent immunosuppressive agent, used in patients receiving hematopoietic stem cell transplant (HSCT) for Graft vs Host disease prophylaxis. Compared to calcineurin inhibitors, sirolimus has no neurotoxicity or nephrotoxicity, but sirolimus causes dose-dependent thrombocytopenia, leukopenia, delayed wound healing, hyperlipidemia, and hypertriglyceridemia. Here we report a case of acute pancreatitis and diabetic ketoacidosis in a patient with sickle cell disease post haploidentical family donor HSCT which was managed conservatively without plasmapheresis.

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