Social disadvantage accelerates aging.

Social disadvantage, like advanced age, is a risk factor for a broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using a multicohort approach, we investigated the associations of social disadvantage with age-related plasma proteins and age-related diseases. We found proteomic signatures of accelerated immune aging and 14 specific age-related proteins linked to social disadvantage during both early and later life.

Incidence of new onset arterial hypertension after metabolic bariatric surgery: an 8-year prospective follow-up with matched controls.

Background: Metabolic bariatric surgery (MBS) reduces the risk of new-onset hypertension; however, it is unclear whether this effect varies according to patient sex, age, or socioeconomic background. This study aimed to assess the risk of new-onset arterial hypertension after MBS, with a special focus on these patient characteristics.

Methods: This follow-up study with matched controls was nested in a large employee cohort, the Finnish Public Sector study, consisting of individuals with no hypertension at baseline.

Association of neighbourhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study.

Socioeconomic disadvantage at individual level is associated with poor cognitive outcomes but the link of neighbourhood disadvantage with cognitive function is unclear. We used data from Young Finns Study, a population-based cohort, to examine the associations of neighbourhood and individual-level disadvantage in childhood (age 3-21 years) and adulthood (age 22 up to the time of cognitive assessment) with cognitive function in mid-adulthood (age 35-49 years). Neighbourhood disadvantage was ascertained based on register data, including geo-coded address history.

Associations of 24-h Movement Behaviors With Incidence of Cardiovascular Risk Factors: The Finnish Retirement and Aging Study.

Low physical activity, high sedentary time (SED), and inadequate sleep increase cardiovascular disease risk, but the codependency between these 24-h movement behaviors has often been neglected. This study examined associations between 24-h movement behaviors and incidence of cardiovascular risk factors. The study included 866 adults (mean age 62.

Winter-time solar radiation, precipitation, and psychotropic medication purchases: A cohort study in Finnish public sector employees.

Background: In Northern latitudes, winter is the darkest time of the year, and depressive episodes during winter are prevalent. Although changing weather patterns due to climate change are projected to result in warmer and wetter and, thus, even darker winters, research on the impact of winter-time natural light and precipitation on mental health is scarce. We examined associations of exposure to solar radiation and precipitation with psychotropic medication and antidepressant purchases in winter months.

Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study.

Background: Regular physical activity is recommended for all aged 5 years and older, but the health benefits gained might differ across population subgroups. The aim of this study was to examine these benefits in terms of years lived free from major non-communicable diseases in subgroups with varying levels of risk factors.

Methods: Our analysis was based on a multicohort study of initially healthy European adults from the IPD-Work Consortium and initially healthy participants from the UK Biobank study.

COVID-19 infection and later risk of sickness absence by socioeconomic status: a cohort study.

Background: The COVID-19 pandemic was a significant health risk and resulted in increased sickness absence during the pandemic. This study examines whether a history of COVID-19 infection is associated with a higher risk of subsequent sickness absence.

Methods: In this prospective cohort study, 32,124 public sector employees responded to a survey on COVID-19 infection and lifestyle factors in 2020 and were linked to sickness absence records before (2019) and after (2021-2022) the survey.

Psychosocial Risks and Resources at Work and Employee Well-being in the Context of the COVID-19 Pandemic: Time Series of Cross-sections.

Objective: We examined the relationships between psychosocial factors and employee well-being in the context of the COVID-19 pandemic.

Methods: Survey data were from Finnish public sector employees from 2018 (T1 = before), 2020 (T2 = during), and 2022 (T3 = after the pandemic) (N= 29,360). Employee well-being was measured with self-rated health, work ability, and recovery from work.

Residential Area Characteristics Are Associated With Asthma Burden in Children.

Background: Wheezing illnesses, especially those triggered by rhinovirus infection, cause a major disease burden, and they often precede asthma. Environmental exposures are known to affect recurrence of wheezing. We investigated the relations of population density, greenness (forested areas), and socioeconomic factors of the living surroundings to the burden of asthma in children with prior bronchiolitis.

Trajectories of work ability and associated work unit characteristics from pre-COVID to post-COVID pandemic period.

Objectives: To identify trajectories of work ability from pre-COVID to post-COVID-19 pandemic period and to examine work unit characteristics associated with these trajectories.

Methods: The study population was a cohort of Finnish public sector employees (n=54 651) followed from 2016 until 2022. We used trajectory analysis to identify trajectories of work ability and multinomial regression to examine their associations with prepandemic work unit characteristics and pandemic-related changes at workplaces.

The role of early life factors and green living environment in the development of gut microbiota in infancy: Population-based cohort study.

Objective: Early life microbial exposure influences the composition of gut microbiota. We investigated how early life factors, and the green living environment around infants' homes, influence the development of gut microbiota during infancy by utilizing data from the Steps to Healthy Development follow-up study (the STEPS study).

Methods: The gut microbiota was analyzed at early (∼3 months, n = 959), and late infancy (∼13 months, n = 984) using 16S rRNA amplicon sequencing, and combined with residential green environment, measured as (1) Normalized Difference Vegetation Index, (2) Vegetation Cover Diversity, and (3) Naturalness Index within a 750 m radius.

Exposure to useable green space and physical activity during active travel: A longitudinal GPS and accelerometer study before and after retirement.

Green spaces may serve as population level interventions encouraging active travel. We examined the associations between exposure to useable green space (CORINE Land Cover categories) and physical activity during active travel (GPS and accelerometer) among late middle-aged participants from the Finnish Retirement and Aging study (n = 102). Greater proportion of useable green space was associated with higher physical activity during active travel on days off (+11 min/day per 1 SD increase in exposure) and on retirement days (+12 min/day), but not on workdays.

COVID-19-induced changes in the workplace, psychosocial work environment and employee well-being: a longitudinal study.

Background: In many workplaces, the coronavirus disease 2019 pandemic changed work arrangements, but there is scarce longitudinal evidence on whether psychosocial work environment and employee well-being were affected.

Aims: To examine the psychosocial work environment and employee well-being before, during and after the pandemic in relation to pandemic-induced changes (working from home, change to other tasks and team reorganization).

Methods: Survey data from a cohort of 20 944 public sector employees in Finland were collected before (2016-2018), during (2020) and after the pandemic (2022).

Stimulating leisure-time activities and the risk of dementia: a multi-cohort study.

Background: Stimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with the risk of dementia across up to two decades' follow-up.

Obesity and risk of diseases associated with hallmarks of cellular ageing: a multicohort study.

Background: Ageing hallmarks, characterising features of cellular ageing, have a role in the pathophysiology of many age-related diseases. We examined whether obesity is associated with an increased risk of developing such hallmark-related diseases.

Methods: In this multicohort study, we included people aged 38-72 years with data on weight, height, and waist circumference measured during a clinical examination at baseline between March 13, 2006, and Oct 1, 2010, from the UK Biobank with follow-up until Nov 12, 2021.

Association of school neighbourhood socioeconomic disadvantage and teaching staff's risk of violence at work.

Aim: The aim of this study was to determine the association between neighbourhood socioeconomic disadvantage and teaching staff's risk of workplace violence and whether workplace psychosocial resources can act as effect modifiers.

Methods: Primary school teaching staff in the six largest cities in Finland responded to a survey in 2018 and were linked to information on school neighbourhood disadvantage obtained from the national grid database ( = 3984).

Results: After adjustment for confounders, staff working in schools located in the most disadvantaged neighbourhoods had a 1.

Physical activity and risk of workplace and commuting injuries: a cohort study.

Objective: Leisure-time physical activity (PA) has been hypothesized to reduce the likelihood of occupational injuries, but it is unclear whether this association varies between workplace and commuting injuries. The aim of this study was to examine the association between PA and risk of workplace and commuting injuries.

Methods: Data were derived from the Finnish Public Sector study including 82 716 person-observations (48 116 participants).

Cohort study on incidence of new-onset type 2 diabetes in patients after bariatric surgery and matched controls.

Background: Metabolic bariatric surgery the reduces risk of new-onset type 2 diabetes in individuals with obesity, but it is unclear whether the benefit varies by sex, age, or socioeconomic status. The aim was to assess the risk of new-onset type 2 diabetes after metabolic bariatric surgery in these subgroups.

Methods: The Finnish Public Sector study, a follow-up study with matched controls nested in a large employee cohort, included patients without type 2 diabetes and with a diagnosis of obesity or self-reported BMI of at least 35 kg/m2.

Are changes in sleep problems associated with changes in life satisfaction during the retirement transition?

Retirement reduces sleep problems, but changes in life satisfaction during the retirement transition are multifactorial and partly unknown. The aim of this prospective cohort study was to examine whether changes in sleep problems are associated with changes in total and domain-specific life satisfaction during the retirement transition (on average 0.5 years before and 0.

Sex-related differential item functioning of the Jenkins Sleep Scale: a cross-sectional study among 77 967 employees in the Finnish public sector.

Objectives: To investigate if the Jenkins Sleep Scale (JSS) demonstrates sex-related differential item functioning (DIF).

Design: Cross-sectional study.

Setting: Survey data from the Finnish Public Sector study (2015-2017).

Climate Change, Summer Temperature, and Heat-Related Mortality in Finland: Multicohort Study with Projections for a Sustainable vs. Fossil-Fueled Future to 2050.

Background: Climate change scenarios illustrate various pathways in terms of global warming ranging from "sustainable development" (Shared Socioeconomic Pathway SSP1-1.9), the best-case scenario, to 'fossil-fueled development' (SSP5-8.5), the worst-case scenario.

Finnish Retirement and Aging Study: a prospective cohort study.

Purpose: The Finnish Retirement and Aging (FIREA) Study was set up to study changes in health behavioural and cardiometabolic risk factors across retirement transition, and to examine the long-term consequences of work and retirement on health and functioning with advancing age.

Participants: Public sector workers whose estimated statutory retirement date was in 2014-2019 were invited to participate by sending them a questionnaire 18 months prior to their estimated retirement date. In the first phase of the FIREA Study, participants were followed up with annual surveys, accelerometer and clinical measurements during retirement transition into post-retirement years.

Downsizing and purchases of psychotropic drugs: A longitudinal study of stayers, changers and unemployed.

Background: The evidence is insufficient regarding the association between organizational downsizing and employee mental health. Our aim was to analyze trajectories of prescribed sedatives and anxiolytics with a sufficiently long follow-up time to capture anticipation, implementation and adaption to a downsizing event among stayers, changers and those who become unemployed compared to unexposed employees.

Method: Residents in Sweden aged 20-54 years in 2007, with stable employment between 2004 and 2007, were followed between 2005 and 2013 (n = 2,305,795).