Polychlorinated biphenyls (PCBs) in the Persian Gulf and Gulf of Oman: baseline report on occurrence, distribution, and ecological risk assessment.

In the present study, 18 polychlorinated biphenyl (PCB) compounds were measured in marine sediments collected from 49 offshore stations in the Persian Gulf and the Gulf of Oman in 2019. After the last oceanographic cruise in 2006, no study has been performed on the offshore sediments of this region, and this is the first study on the PCBs in this area. The total amount of PCB compounds in the sediment samples ranged from 74.

Pesticide residues in fresh Mazafati date fruit, soil, and water, and assessment of potential health risks to consumers.

A quantitative method based on quick, easy, cheap, effective, rugged, and safe technique (QuEChERS) sample extraction and ultra-performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) was evolved for the determination of 47 pesticide residues in fresh Mazafati date fruits from Bam City of Kerman Province, Iran. The recoveries for selected pesticides ranged from 88 to 110% with a relative standard deviation (RSD) of less than 20% at concentrations of 0.05 and 0.

Obeticholic acid-loaded exosomes attenuate liver fibrosis through dual targeting of the FXR signaling pathway and ECM remodeling.

End-stage of liver fibrosis as a precancerous state could lead to cirrhosis and hepatocellular carcinoma which liver transplantation is the only effective treatment. Previous studies have indicated that farnesoid X receptor (FXR) agonists, such as obeticholic acid (OCA) protect against hepatic injuries. However, free OCA administration results in side effects in clinical trials that could be alleviated by applying bio carriers such as MSC-derived exosomes (Exo) with the potential to mimic the biological regenerative effect of their parent cells, as proposed in this study.

Different sized gold nanoparticles for array-based sensing of pesticides and its application for strawberry pollution monitoring.

The use of pesticides plays an essential role in improving crop quality and yield, however, it causes air, water, and soil pollution and the residue of these pesticides in agricultural products threatens the ecosystem and human life. Therefore, it is highly desirable to develop rapid, simple, and cost-effective methods for regular monitoring of pesticide residues in agricultural products especially strawberry that is consumed fresh and unpeeled. In this study, gold nanoparticles (AuNPs) of varying sizes have been exploited as sensing units to design a non-enzymatic colorimetric sensor array for the detection and discrimination of various pesticides including; bifenazate (BF), paraquat (PQ), diazinon (DZ), thiometon (TM), and carbendazim (CD) and chlorpyrifos (CP).

Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review.

Endocrine-disrupting chemicals (EDCs) are a growing public health concern worldwide. Consumption of foodstuffs is currently thought to be one of the principal exposure routes to EDCs. However, alternative ways of human exposure are through inhalation of chemicals and dermal contact.

Probabilistic risk assessment of endocrine disrupting pesticides in Iran.

The chronic dietary risk assessment for 34 pesticides suspected of acting as endocrine disrupters in Iran was assessed by comparing TMDI with the Acceptable Daily Intakes (ADI). Of 34 investigated endocrine-disrupting pesticides (EDPs), 6 had TMDI > ADI. In addition, potential non-carcinogenic and carcinogenic health risk assessments were evaluated using Monte Carlo simulation.

Concentration and non-dietary human health risk assessment of pesticide residues in soil of farms in Golestan province, Iran.

Detection of pesticide residues in soil samples was conducted using UHPLC-MS/MS. Non-dietary health risk assessment was conducted using calculate chronic daily intake (CDI) from ingestion, inhalation and dermal contact pathways and following non-carcinogenic and carcinogenic risks in the adults and adolescent. The rank order of pesticide in soil based on their concentration was malathion (0.

Carcinogenic and non-carcinogenic risk assessment induced by pesticide residues in fresh pistachio in Iran based on Monte Carlo simulation.

This research is aimed at the analysis of 87 pesticides in 30 fresh pistachio samples prepared from stores in Iran by QuEChERS-ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The results showed at least one pesticide was in 67% of fresh pistachio samples. Kresoxim methyl residue was detected in 20 samples with average of 0.

From waste to health: Application of MOF modified walnut biochars for the determination of twenty pesticides in wheat flour by ultra-high performance liquid chromatography-tandem mass spectrometry.

In this research, walnut shell along with a Ni-metal organic framework (Ni-MOF) was thermally treated to obtain a highly efficient biochar. A µ-solid phase extraction (µ-SPE) setup containing the optimized walnut modified biochar was implemented for the extraction of 20 wheat specified pesticides with a wide range of polarities. The modified biochars were characterized and the role of Ni-MOF on the porosity of the obtained biochars was investigated.

Ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis, and probabilistic risk assessment.

Contamination of food with mycotoxins can pose harmful effects on the health of consumers in the long term. Coffee contamination with mycotoxins has become a global concern. This study attempted to meta-analyze the concentration and prevalence of ochratoxin A (OTA) in coffee products and estimate consumers' health risks.

Toxicity, metabolism, and mitigation strategies of acrylamide: a comprehensive review.

Acrylamide, a food-borne chemical toxicant, has raised global concern in recent decades. It mainly originated from reducing sugar and free amino acid interactions in the carbohydrate-rich foodstuffs heated at high temperatures. Due to the neurotoxicity and carcinogenicity of AA, the mechanism of formation, toxic effects on health, and mitigation strategies, including conventional approaches and innovative technologies, have been of great interest since its discovery in food.

Cell proliferation assay for determination of estrogenic components in food: a systematic review.

Due to the widespread use and environmental pollution of estrogenic chemicals, the need for screening tests to detect these compounds is felt more than ever. These compounds lead to cell proliferation. Therefore, studies used cell proliferation to evaluate estrogenic compounds was studied in this systematic review.

National probabilistic risk assessment of newly registered pesticides in agricultural products to propose maximum residue limit (MRL).

Following the EPA recommended method, a chronic diet risk assessment for pesticides was recently performed for adults and children in the Iranian population. The National Theoretical Maximum Daily Intake (NTMDI) for 32 pesticides was computed using the theoretical maximum residue limits (MRLs) of food consumption regulations and data from the comprehensive database of the Iranian Research Institute of Plant Protection (IRIPP). The risk was assessed by comparing TMDI with the acceptable daily intakes (ADI) evaluated by FAO.

A systematic review of the concentration of potentially toxic elements in fish from the Persian Gulf: A health risk assessment study.

Fish as a critical food source is responsible for supplying nearly 20% of the average per capita animal protein for 3.2 billion people worldwide. However, oral exposure to potentially toxic elements (PTE) such as mercury (Hg), cadmium (Cd), lead (Pb), and arsenic (As) through marine fish consumption can cause health risks in consumers.

Physicochemical properties of saponin containing extract: example application in foam stability and qualitative parameters for malt beverage industry.

Aqueous Extract of root (AE) exhibited remarkable foaming profile, emulsification properties and antifungal activity due to the presence of high concentration of total saponins. Total phenolic compounds, another main component, accounted for the AE antioxidant activity. Spray drying of AE, as a thermal process, did not affect the foaming indices of Spray-dried Extract (SE) and is a recommended alternate for convenient application in food industry.

Investigation and probabilistic health risk assessment of pesticide residues in cucumber, tomato, and okra fruits from Khuzestan, Iran.

In this study, 30 pesticide residues in 45 fresh-eating cucumber, tomato, and okra fruit samples collected from the Khuzestan province as the main agricultural products in Iran using the QuEChERS extraction method were analyzed. In addition, noncarcinogen and carcinogen health risk assessments were evaluated. Results indicated that 93% of cucumber samples had at least one pesticide, of course, less than the maximum residue limit (MRL).

Determination of multi-class pesticides residues of cow and human milk samples from Iran using UHPLC-MS/MS and GC-ECD: A probabilistic health risk assessment.

Raw, pasteurized, powdered cow milk and human milk samples from Tehran, Iran were investigated for the residual of fifty pesticides with the aid of gas chromatography coupled with electron capture detector (GC-ECD) and mass detector for confirmation; and ultra-high performance liquid chromatography-tandem mass spectroscopy (UHPLC-MS/MS). No pesticide residue was determined in more than 91% of examined samples. However, the dimethoate residue was detected in 3 raw milk samples in levels higher than EU recommended MRL.

Pesticide residues in green-house cucumber, cantaloupe, and melon samples from Iran: A risk assessment by Monte Carlo Simulation.

This research aims to analyze 56 pesticide residues in 100 green-house cucumber and 150 cantaloupe and melon samples collected from markets in Iran by Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) extraction method based on analysis with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). In addition, non-carcinogenic and carcinogenic probabilistic health risk assessments were evaluated by Hazard Quotient (HQ), Hazard Index (HI), and Carcinogenic Risk (CR) based on the Monte Carlo Simulation (MCS) method. According to Iranian regulation, 18% of cucumber and 22% of cantaloupe and melon samples were contaminated by at least one pesticide.

Carcinogenic and non-carcinogenic risk assessment induced by pesticide residues in commercially available ready-to-eat raisins of Iran based on Monte Carlo Simulation.

Pesticide residues in fruits lead to serious public health and environmental problems. This study was undertaken to analyze 57 pesticides residues in 60 commercially available ready-to-eat packed raisins samples from Iran's markets using Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach along with acetonitrile for the extraction, surface adsorbents for clean-up procedure, following with an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Moreover, the probabilistic health risk assessment includes non-carcinogenic and carcinogenic risk were estimated by hazard quotient (HQ), Hazard Index (HI) and cancer risk (CR) using the Monte Carlo Simulation (MCS) method.

Evaluation of pesticide residues and risk assessment in apple and grape from western Azerbaijan Province of Iran.

West Azerbaijan, especially the city of Urmia, is the center of Iranian apple and grape production hence the importance of this, residues of 85 pesticides in these products were investigated using modified QuEChERS extraction followed by UHPLC-MS/MS technique. Residues of 17 different pesticides detected in some apple samples. In grape sample only 7 pesticides detected.

Preparation and evaluation of various banana-based biochars together with ultra-high performance liquid chromatography-tandem mass spectrometry for determination of diverse pesticides in fruiting vegetables.

Biomass, originates from plant- or animal-based materials with a huge potential to be reused. Here we report a simple, rapid and inexpensive method for preparation of modified biochars derived from the banana peel followed by their applications in pipette-tip micro solid-phase extraction (PT-µSPE). Due to the contribution of various effective parameters on modification of banana peel biochars (BPBs), Taguchi design was used to optimize activation temperature, activation repetition, treatment material and impregnation ratio.

Probabilistic health risk assessment based on Monte Carlo simulation for pesticide residues in date fruits of Iran.

The validation of an analytical procedure based on the quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach is presented for multiresidue analysis of pesticides in dates by liquid chromatography-tandem mass spectrometry (UHPLC-MS). The proposed methodology was applied for simultaneous quantification of 16 pesticides in 50 different date fruits. Method validation was performed regarding accuracy, precision, LDR, LOD, and LOQ, as well as matrix effects.

Simultaneous detection and identification of thiometon, phosalone, and prothioconazole pesticides using a nanoplasmonic sensor array.

In this work, a colorimetric sensor array has been designed for the identification and discrimination of thiometon (TM) and phosalone (PS) as organophosphate pesticides and prothioconazole (PC) as a triazole pesticide. For this purpose, two different plasmonic nanoparticles including unmodified gold nanoparticles (AuNPs) and unmodified silver nanoparticles (AgNPs) were used as sensing elements. The principle of the proposed strategy relied on the aggregation AuNPs and AgNPs through the cross-reactive interaction between the target pesticides and plasmonic nanoparticles.

Health risk assessment of neonicotinoid insecticide residues in pistachio using a QuEChERS-based method in combination with HPLC-UV.

There is an increasing need to address the potential risks arising from combined exposures to multiple residues from pesticides in the diet. Pesticide residue-related pollution is a problem that arises because of the increased use of pesticides in agriculture to meet the growing demands of food production. In this study, pesticide residue data were obtained based on an optimized extraction method.