Vitreous and Aqueous Penetration of Orally Administered Trimethoprim-Sulfamethoxazole Combination in Humans.

Purpose: To determine the penetration of orally administered trimethoprim (TMP)-sulfamethoxazole (SMX) into the aqueous and vitreous cavity of noninflamed human eyes.

Methods: Nine adult patients undergoing cataract surgery and 10 adult patients undergoing pars plana vitrectomy were given 3 doses of oral TMP-SMX every 12 hours before the surgery. Aqueous and blood samples were collected from patients undergoing cataract surgery; vitreous and blood samples were collected from patients undergoing vitrectomy.

The safety and efficacy of linezolid and daptomycin as an additive in Optisol-GS against methicillin-resistant Staphylococcus aureus.

Purpose: To evaluate the efficacy of adding either linezolid or daptomycin to Optisol-GS donor storage medium in reducing methicillin-resistant Staphylococcus aureus (MRSA) contamination of donor corneas.

Methods: Optisol-GS was supplemented with either linezolid at 2×, 4×, or 10× minimum inhibitory concentration (MIC) or daptomycin and calcium at 5× or 50× MIC. Unsupplemented control groups were also used.

Laser in situ keratomileusis flap complications using mechanical microkeratome versus femtosecond laser: retrospective comparison.

Purpose: To compare the incidence of flap complications after creation of laser in situ keratomileusis (LASIK) flaps using a zero-compression microkeratome or a femtosecond laser.

Setting: John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA.

Comparison of simulated keratometric changes induced by custom and conventional laser in situ keratomileusis after myopic ablation: retrospective chart review.

Purpose: To determine the relationship between the achieved refractive change and the change in simulated keratometry (K) after myopic laser situ keratomileusis (LASIK) and compare this relationship between custom and conventional treatments.

Setting: Department of Ophthalmology, University of California, Davis, Sacramento, California, and John A. Moran Eye Center, Salt Lake City, Utah, USA.

Intraocular lens power calculation after corneal refractive surgery.

Cataract surgery after corneal refractive surgery can be challenging for the ocular surgeon due to the difficulty with accurate intraocular lens (IOL) power determination and unexpected refractive surprises. As clinicians have done more work, a number of error sources have been determined. Furthermore, an increasing number of methods to avoid these refractive surprises have been proposed.

Nepafenac-associated bilateral corneal melt after photorefractive keratectomy.

Purpose: We are reporting a case of bilateral corneal melt after photorefractive keratectomy requiring bilateral corneal transplantations.

Results: A 35-year-old man underwent uncomplicated photorefractive keratectomy and was treated postoperatively with topical nepafenac, one drop in both eyes every 2 hours. Three days into this course of treatment, the patient developed bilateral irritation and the dose was decreased to one drop every 4 hours.

Infectious and noninfectious keratitis after laser in situ keratomileusis Occurrence, management, and visual outcomes.

Purpose: To retrospectively review the occurrence, treatment, and visual outcomes associated with various etiologies of keratitis as a postoperative complication of laser in situ keratomileusis (LASIK) at an academic surgical center.

Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

Infectious scleritis after pars plana vitrectomy because of methicillin-resistant Staphylococcus aureus resistant to fourth-generation fluoroquinolones.

Purpose: To describe a case of infectious scleritis caused by methicillin-resistant Staphylococcus aureus (MRSA) after pars plana vitrectomy despite treatment with topical fourth-generation fluoroquinolones.

Methods: Single interventional case report.

Results: A 72-year-old man presented with scleral thinning and subconjunctival abscess 1 month after pars plana vitrectomy.

Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones: a retrospective observational case series.

Objective: To estimate the rate of acute postoperative endophthalmitis after uncomplicated cataract surgery in patients treated before and after surgery with 1 of 2 different fourth-generation fluoroquinolone ophthalmic drops for surgical prophylaxis.

Design: Retrospective, multicenter, observational case series.

Participants: Included in this study were 20,013 patients from 9 cataract surgery centers in 7 states in the United States.

Fourth-generation fluoroquinolone-resistant bacterial keratitis after refractive surgery.

We report the first 2 cases of bacterial keratitis resistant to fourth-generation fluoroquinolones after laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). The first patient had Pseudomonas aeruginosa keratitis after PRK despite treatment with moxifloxacin. The second patient was on gatifloxacin post-LASIK when she had methicillin-resistant Staphylococcus aureus (MRSA) keratitis diagnosed.

Laser in situ keratomileusis in patients with corneal guttata and family history of Fuchs' endothelial dystrophy.

Purpose: To report 1-year results of laser in situ keratomileusis (LASIK) in 7 eyes with corneal endothelial guttata and a family history of Fuchs' endothelial dystrophy.

Setting: John Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

Methods: A retrospective chart review was performed of 4 patients (7 eyes) who had trace to 1+endothelial guttata and a family history of Fuchs dystrophy and then had uneventful LASIK for the correction of myopia and myopic astigmatism.

Nomogram-based intraocular lens power adjustment after myopic photorefractive keratectomy and LASIK: a new approach.

Purpose: (1) To evaluate the accuracy of nomogram-based adjustment of intraocular lens (IOL) power to achieve a desired refractive target after cataract surgery in postmyopic LASIK and photorefractive keratectomy (PRK) eyes and (2) to compare the accuracy of the nomogram-based method with the clinical history method.

Design: Multicenter, retrospective, interventional, noncomparative case series.

Subjects: Fourteen patients (19 eyes) after myopic LASIK or PRK with visually significant cataracts.

Reversible amantadine-induced corneal edema in an adolescent.

Purpose: To document reversible corneal edema caused by amantadine in a pediatric patient.

Methods: A 14-year-old boy with a neurologic tremor was referred for bilateral visual loss. Our examination disclosed bilateral corneal edema without ocular inflammation.

Intraocular lens power calculation after corneal refractive surgery.

Purpose Of Review: Keratorefractive procedures designed to decrease refractive errors have gained enormous popularity among ophthalmologists and patients. As the post-refractive surgery patient population ages, visually significant cataracts will develop. With advances in techniques for cataract extraction and intraocular lens implantation, cataract surgery has evolved into a refractive surgical procedure as well as an operation to improve best corrected visual acuity.

Fishhook injuries of the eye: report of a case and review of management.

A 29-year-old African American man presented to the emergency department at the University of Arkansas for Medical Sciences with a fishhook perforating the cornea of the left eye (OS) extending into the anterior chamber. The fishhook was removed via its entrance wound and was subsequently repaired. Fishhook injuries to the eye can result in profound visual impairment.

The relationship between first postoperative day epithelial status and eventual health of the ocular surface in penetrating keratoplasty.

Purpose: To determine a possible relationship between donor epithelial status on the first postoperative day after keratoplasty and the eventual health of the corneal surface.

Methods: We analyzed 91 patients who underwent penetrating corneal transplantation between January 1998 and January 2000, monitoring the epithelial status of the corneas with fluorescein staining using slit-lamp biomicroscopy. Recipient pre- and postoperative variables and donor characteristics were recorded.