Publications by authors named "Vahabi M"

Article Synopsis
  • Cervical cancer screening, particularly through the Pap test, is not equally accessible for marginalized groups like sex workers and ex-prisoners in Ontario, prompting a study on the viability of HPV self-sampling as an alternative.
  • Involving 84 participants aged 25-69, the study found that most had limited knowledge about cervical cancer, but 88% chose to use HPV self-sampling, with a significant portion testing positive for high-risk HPV types.
  • The study highlights the need for community-based sexual health education and support for HPV self-sampling, emphasizing its acceptability among participants who often experience healthcare discrimination and lack primary care access.
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  • - There has been significant progress in the treatment of biliary tract cancers (BTC) with the introduction of targeted therapies and immunotherapy, moving past years of stagnation in treatment options.
  • - The overview covers existing therapies like FGFR, IDH, and HER2 inhibitors, along with emerging targets such as KRAS and pathways like MAPK and PI3K/AKT/mTOR, plus newer therapeutic approaches like CAR-T and vaccines.
  • - Challenges include a limited patient pool for targeted therapies, with discussions on how to design clinical trials effectively, along with insights into promising trials that could change BTC treatment practices.
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  • - The study highlights the challenges in integrating AI into cardiology due to insufficient evidence supporting its effectiveness compared to human experts or existing standard practices.
  • - A systematic review identified 64 studies from 2015 to 2023 that prospectively validated AI interventions in cardiology, revealing that most studies showed AI outperformed or matched human experts, particularly in areas like imaging and arrhythmia.
  • - Despite the promising results, the review stresses the need for more randomized controlled trials and emphasizes ongoing validation to assess AI's effectiveness in real-world clinical settings.
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  • - Nontuberculous mycobacteria (NTM) are becoming more common, with Mycobacterium fortuitum being a rapidly reproducing type that can lead to severe infections, especially in people with weakened immune systems.
  • - Diagnosing infections like those caused by M. fortuitum is complicated, as it's tough to tell if bacteria found in cultures are causing an infection or are just contaminants.
  • - Unlike tuberculosis, M. fortuitum doesn't respond to standard antituberculosis treatments; instead, it requires a combination of antibiotics such as quinolones, doxycycline, and others for effective treatment, which will be illustrated through a case study of a 2-year skin infection.
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Background: Lung cancer is one of the most common cancers and causes of cancer death in Canada. Some previous literature suggests that socioeconomic inequalities in lung cancer screening, treatment and survival may exist. The objective of this study was to compare overall survival for immigrants versus long-term residents of Ontario, Canada among patients diagnosed with lung cancer.

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Background: Distinguishing benign from malignant pancreaticobiliary disease is challenging because of the absence of reliable biomarkers. Circulating extracellular vesicles (EVs) have emerged as functional mediators between cells. Their cargos, including microRNAs (miRNAs), are increasingly acknowledged as an important source of potential biomarkers.

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Background: Mental illnesses and mental health challenges have become increasingly pervasive among Chinese university students. However, the utilization rate of mental health services is low among students.

Aims: We aimed to explore Chinese university students' help-seeking behaviors to understand how they deal with mental health challenges and use the results to inform the development of effective mental health promotion initiatives.

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RPL- (usually pronounced "ripple")-is the standard for IoT networks. However, it neglects to exploit IoT devices' full capacity to optimize their transmission power, mainly because it is quite challenging to do so in parallel with the routing strategy, given the dynamic nature of wireless links and the typically constrained resources of IoT devices. Adapting the transmission power requires dynamically assessing many parameters, such as the probability of packet collisions, energy consumption, the number of hops, and interference.

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Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with limited treatment options, highlighting the urgent need for innovative approaches. A promising target for new anticancer therapies across various tumor types is the receptor tyrosine kinase c-MET. Here, we examined the impact of the c-MET inhibitor tivantinib in combination with gemcitabine on both primary and immortalized PDAC cells, and we investigated the mechanism underlying this combined treatment's effects.

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The study was performed in two phases. First, the polymerization was carried out upon three magnetized surfaces of silica aerogel, zeolite Y, and MIL-101(Cr). Then, optimal molecularly imprinted polymer and optimal extraction conditions were determined by the central composite design-response surface method.

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According to the Center for Disease Control and Prevention's National Breast and Cervical Cancer Early Detection Program, the cervical cancer screening rate dropped by 84% soon after the declaration of the COVID-19 pandemic. The challenges facing cervical cancer screening were largely attributed to the required in-person nature of the screening process and the measures implemented to control the spread of the virus. While the impact of the COVID-19 pandemic on cancer screening is well-documented in high-income countries, less is known about the low- and middle-income countries that bear 90% of the global burden of cervical cancer deaths.

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Importance: Breast, cervical, and colorectal cancer-screening disparities existed prior to the COVID-19 pandemic, and it is unclear whether those have changed since the pandemic.

Objective: To assess whether changes in screening from before the pandemic to after the pandemic varied for immigrants and for people with limited income.

Design, Setting, And Participants: This population-based, cross-sectional study, using data from March 31, 2019, and March 31, 2022, included adults in Ontario, Canada, the country's most populous province, with more than 14 million people, almost 30% of whom are immigrants.

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The aim of this study was to investigate the effect of the age of second language acquisition on auditory binaural and temporal processing in three groups of early and late Persian-English bilingual and Persian monolingual children. The sample consisted of 63 subjects aged between 9 and 13 years, divided into: 21 monolingual, 21 early bilingual and 21 late bilingual children. The individuals were underwent to the Dichotic digits (DD), Pitch Pattern Sequence (PPS), Duration Pattern Sequence (DPS) and gaps in noise (GIN) tests.

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Article Synopsis
  • Pancreatic ductal adenocarcinoma (PDAC) is a very serious type of cancer, and it's hard to improve people's chances of surviving for five years after diagnosis.
  • There are difficulties in finding this cancer early and treating it because it's aggressive and doesn't respond well to current treatments.
  • Researchers are looking at tiny bubbles called extracellular vesicles (EVs) to help find new ways to detect and treat PDAC, but there are challenges in using them reliably.
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Soil contamination with heavy metals adversely affects plants growth, development and metabolism in many parts of the world including arid and semi-arid regions. The aim of this study was to investigate the single and combined effects of drought and copper (Cu) stresses on seed yield, and biochemical traits of Fumaria parviflora in a split - factorial experiment at Research Field of Payam-E-Noor university of Kerman during 2019. The collected seeds from two Cu contaminated regions were evaluated under drought and Cu (0, 50, 150, 300, and 400 mg/kg) stresses.

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There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis.

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Chemoresistance constitute a major obstacle in cancer treatment, leading to limited options and decreased patient survival. Recent studies have revealed a novel mechanism of chemoresistance acquisition: the transfer of information via exosomes, small vesicles secreted by various cells. Exosomes play a crucial role in intercellular communication by carrying proteins, nucleic acids, and metabolites, influencing cancer cell behavior and response to treatment.

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With appropriate screening, cervical cancer can be prevented. In Ontario, Canada, some groups of women have low screening rates. South Asian, Middle Eastern and North African women are particularly at risk of under-screening.

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Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor prognosis due to early metastasis, low diagnostic rates at early stages, and resistance to current therapeutic regimens. Despite numerous studies and clinical trials, the mortality rate for PDAC has shown limited improvement. Therefore, there is a pressing need to attain.

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In a study to understand acceptability and uptake of Human Papilloma Virus (HPV) self-sampling, we engaged community champions to lead recruitment and other study activities. This article describes qualitative findings relevant to the role of the community champion. We found that community champions were critical to promoting awareness about and encouraging cervical screening and HPV self-sampling.

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Background: While cervical cancer deaths have declined steeply in high-income countries due to the widespread use of the Papanicolaou test (Pap test), the same trend has not emerged in low or middle-income countries (LMICs). Access to screening in LMICs like India is limited due to barriers such as limited healthcare infrastructures, lack of sexual health education, and stigma demarcating sexually transmitted infections (STIs). HPV self-sampling (HPV-SS), a woman-centered and at-home method for screening, can be utilized as a unique screening tool to overcome some of these barriers.

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