Design, synthesis, docking studies and bioactivity evaluation of 1,2,3-triazole eugenol derivatives.

The design, synthesis, docking studies and evaluation of the antifungal and cytotoxic properties of eugenol (EUG) containing 1,2,3-triazole derivatives are reported. Most of the derivatives have not been reported. The EUG derivatives were synthesized, molecular docked and tested for their antifungal activity.

Chemical composition and effect of essential oils of and on adults and ovigerous masses of .

Fasciolosis is a worldwide distribution zoonosis that causes great damage in ruminant breeding and has the aquatic mollusc as an intermediate host. Synthetic molluscicides are the most used for control; however, they are harmful to fauna and flora. Therefore, this study aimed to evaluate the effect of essential oils from , , and terpene carvacrol, on adult molluscs and eggs of .

Inclusion complex of ketoconazole and p-sulfonic acid calix[6]arene improves antileishmanial activity and selectivity against Leishmania amazonensis and Leishmania infantum.

Many previous studies presented the effectiveness of ketoconazole (KTZ) against leishmaniasis. However, the bioavailability and therapeutic efficacy of free KTZ are limited due to its low aqueous solubility. In this study, an inclusion complex (IC6HKTZ) was prepared with p-sulfonic acid calix[6]arene (CX6SOH) to improve the solubility and efficacy of KTZ against Leishmania amazonensis and Leishmania infantum promastigotes.

Ketoconazole/calix[n]arenes-based compounds improve the antifungal activity against azole-resistant Candida isolates.

Ketoconazole (KTZ) is an antifungal agent; however, its bioavailability and therapeutic efficacy are reduced by the low aqueous solubility of the drug. Aiming at providing to improve the biopharmaceutical properties of KTZ, we studied the water-soluble different calix[n]arenes as carrier systems for KTZ. All calix[n]arene-KTZ tested showed in vitro antifungal activity superior or similar to free KTZ against Candida spp.

Bioactivity of Meliaceae, Amaryllidaceae, Solanaceae and Amaranthaceae plant aqueous extracts against the cattle tick .

Commercial synthetic acaricides have selected resistant populations of , and generate residues in the environment or in milk/cattle products. In this study, aqueous extracts (AE) from (Maz), , , (Nta) and were evaluated for the bioactivity against the cattle tick. The treatment using Nta or Maz AE resulted in the lowest egg hatching rate (34.

Chemical composition and effect of (L.) mosyakin & clemants essential oil on (D'Orbigny, 1835).

(L.) Mosyakin & Clemants, known as santa maria herb, is a medicinal plant used on pest control and to treat parasitic diseases. Due to its potential for pest control, the aim of this work was to determine the chemical composition of essential oil and evaluate its molluscicidal effect on , which is an intermediate host for the trematode, that is responsible for causing human schistosomiasis.

Environmental risk assessment for sustainable pesticide use in coffee production.

The extensive use of pesticides in agricultural practices has been associated with human health problems and environmental contamination worldwide. Brazil is the largest consumer of pesticides in the world and Espírito Santo State stands out as the second Brazilian producer of coffee. However, there is no information about environmental impact of coffee producing at Itapemirim River Basin (IRB) region, Espírito Santo State, Brazil; hence a simple and quick method using open access softwares (AGROSCRE and ARAquá Web) to estimate surface entrainment and pesticide leaching potential was carried out.

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria.

Ureases are enzymes that hydrolyze urea into ammonium and carbon dioxide. They have received considerable attention due to their impacts on living organism health, since the urease activity in microorganisms, particularly in bacteria, are potential causes and/or factors contributing to the persistence of some pathogen infections. This review compiles examples of the most potent antiurease organic substances.

Spatial and temporal distribution of urban heat islands.

The formation of an urban heat island (UHI) is one of the most common impacts of the urbanization process. To mitigate the effects of UHI, the planning of urban forests (e.g.

Geotechnology and landscape ecology applied to the selection of potential forest fragments for seed harvesting.

The Atlantic Forest biome is recognized for its biodiversity and is one of the most threatened biomes on the planet, with forest fragmentation increasing due to uncontrolled land use, land occupation, and population growth. The most serious aspect of the forest fragmentation process is the edge effect and the loss of biodiversity. In this context, the aim of this study was to evaluate the dynamics of forest fragmentation and select potential forest fragments with a higher degree of conservation for seed harvesting in the Itapemirim river basin, Espírito Santo State, Brazil.