Publications by authors named "Vagner Madrini"
Article Synopsis
- Mineralocorticoid receptor antagonists (MRA) like spironolactone are effective for heart failure with reduced ejection fraction but are often underused due to hyperkalemia concerns.
- The REALIZE-K trial tested the effects of sodium zirconium cyclosilicate (SZC) in helping patients with heart failure and hyperkalemia effectively use spironolactone.
- Results showed that participants who received SZC had significantly better outcomes in terms of maintaining normal potassium levels and continuing on spironolactone compared to those on a placebo.
Background: Mineralocorticoid receptor antagonists (MRAs) improve outcomes in patients with heart failure and reduced ejection fraction (HFrEF). However, MRAs are often underused because of hyperkalemia concerns.
Objectives: The purpose of this study was to assess whether sodium zirconium cyclosilicate (SZC), a nonabsorbed crystal that traps and rapidly lowers potassium, enables MRA use in patients with HFrEF and prevalent hyperkalemia (or at high risk).
Article Synopsis
- - Giant cell arteritis (GCA) is a chronic inflammation of medium and large arteries, often linked to issues with the aorta and the formation of aneurysms.
- - Although rare, GCA can also affect heart valves, leading to valvulitis with the presence of giant cells.
- - The case study discusses a 50-year-old woman who had an aortic aneurysm and valve insufficiency, which was confirmed through tissue examination to have giant-cell involvement in both her aorta and heart valve.
Impact of COVID-19 Pandemic in a Brazilian High-Volume Aortic Center.
Braz J Cardiovasc Surg
April 2021
Introduction: The coronavirus disease 2019 (COVID-19) pandemic brought an unprecedented lack of control of what was to come. The intent of this document is to provide a balance of how much was ceased to be done for patients with aortic disease, to assess the mortality of these patients, and to show what happened to those who became COVID-19 positive during their hospitalization.
Methods: From April 1st to July 31st 2020, the worst period of the pandemic in São Paulo, Brazil, the Institute's aortic surgical patients operated on were evaluated and those were compared with patients operated during the same period in 2019.