Publications by authors named "Vagia Patsoukaki"
Endocrinology
November 2023
Article Synopsis
- Catecholamine-stimulated lipolysis decreases with age, leading to increased fat accumulation and insulin resistance, linked to the function of OCT3, a transporter inhibited by estradiol (E2).
- The study involved analyzing subcutaneous adipose tissue (SAT) from women of varying ages and diabetes statuses to measure OCT3 mRNA levels and their correlation to insulin resistance.
- Results showed that OCT3 mRNA and protein levels rise with age and postmenopause, but decrease with E2 treatment, suggesting that higher OCT3 levels may impair lipolysis and contribute to insulin resistance in older women.
Diab Vasc Dis Res
June 2023
Article Synopsis
- - SMARTEST is a clinical trial comparing the effectiveness of dapagliflozin and metformin in early-stage type 2 diabetes, focusing on microvascular complications tracked by the Swedish National Diabetes Register (NDR).
- - The study validated the accuracy of microvascular complication data from the NDR by comparing it with electronic health records (EHRs) from 276 participants over three years, finding a high agreement rate across various health indicators.
- - Results showed strong correlations between the NDR and EHR data, supporting the reliability of national health care registries for collecting endpoint data in clinical trials like SMARTEST.
