Publications by authors named "Vadyukhin M"
Article Synopsis
- Kidney disease is becoming a major global health concern, with projections indicating it will rank as the fifth-leading cause of life lost by 2040.
- The research focuses on understanding the dose-dependent effects of electron irradiation on renal tissue, as the impact of this type of radiation is not well studied compared to others like gamma and X-rays.
- Findings show that higher doses of electron irradiation cause increased oxidative stress, inflammation, and significant damage to kidney tissue, including apoptosis and early fibrosis, highlighting the importance of managing radiation doses to protect kidney function.
Article Synopsis
- Radiotherapy can lead to premature ovarian failure and infertility in cancer patients, highlighting the need for ovarian radioprotection methods.
- Electron irradiation is a promising but under-researched option that has less toxic effects on surrounding tissues compared to other radiation types.
- The study shows that leukocyte-poor platelet-rich plasma can mitigate the negative effects of electron irradiation on ovarian function by promoting healing and reducing inflammation through specific cellular mechanisms.
Background: Research on the subject of the influence of SARS-CoV-2 mechanisms on human homeostasis remains an actual problem. Particular interest is the study of pathomorphological changes in the appendix in children with COVID-19.
Objectives: Aim of this study: morphological and molecular biological evaluation of the appendix in children of different age groups with COVID-19.
Background: Skin cancer is the most frequently diagnosed type of cancer among all malignant neoplasms. The decrease in mitotic activity and the death of intact keratinocytes arise due to the constantly renewing epithelium being highly sensitive to ionizing radiation.
Aim: The aim of the study is immunohistochemical evaluation of the proliferative-apoptotic balance of keratinocytes, the fibrous component of the skin, and the expression of pro-inflammatory and anti-inflammatory cytokines after single or fractional local electron irradiation.
Background: At present, the damage of male reproductive function caused by electron irradiation, as well as the development of methods for its correction are the relevant topics for further research. In fact, the effect of leukocyte-poor platelet-rich plasma (LP-PRP) growth factors are poorly investigated on different aspects of male fertility.
Methods: In this study, Wistar rats were divided into four groups; I) control which were injected with saline; II and III) groups (n=65) whose testes were locally irradiated with electrons to a dose of 2 Gy (linear accelerator "NOVAC-11"); III) the group (n=30) which received LP-PRP for 11 weeks after irradiation; and IV) animals (n=30) which received only LP-PRP (conditional control).
Based on studies that focused on the effect of SARS-CoV-2 on human tissues, not only pulmonary invasion was revealed, but also impaired testicular function. Thus, the study of the mechanisms of influence of SARS-CoV-2 on spermatogenesis is still relevant. Of particular interest is the study of pathomorphological changes in men of different age groups.
View Article and Find Full Text PDFBackground And Purpose: With the emergence of linear accelerators in radiotherapy, it becomes necessary to accurately select new dosing regimens. The purpose of this study was to assess the morphological changes of spermatogenesis after radiation exposure.
Materials And Methods: Male Wistar rats (n = 40) were subjected to targeted ionizing radiation on a pulsed electron accelerator "NOVAC-11" with doses of 2, 8 and 12 Gy.
Background: The number of cases of male infertility is steadily growing every year, and therefore it is necessary to develop new methods for the diagnosis and treatment of this disease. It is known that plasma enriched with platelets, the α-granules of which contain growth factors, possesses high regenerative activity; therefore, we can expect positive results from its use for the restoration of spermatogenic epithelium.
Objective: Morphological assessment of spermatogenesis after local β-irradiation with a dose of 8 Gy and the introduction of growth factors.
Materials And Methods: Experimental animals ( = 135) were divided into 5 groups: I - control ( = 10); II - 2IR ( = 35; 2 Gy); III - 2IR + LP-PRP + IGF-1 ( = 30); IV - 2IR + LP-PRP ( = 30); V - LP-PRP ( = 30).
Results: Electron irradiation reduces the number of germ cells in comparison with the control group. After injection of LP-PRP + rhIGF-1 significantly increased the number of germ cells, Sertoli and Leydig cells, the height of germinal epithelium, area and diameter of seminiferous tubules.