Publications by authors named "Vadlamudi Karunakar"
Article Synopsis
- This study investigates the role of right atrial (RA) and right ventricular (RV) dynamics in predicting outcomes for children with pulmonary arterial hypertension (PAH).
- Researchers analyzed clinical data from 57 children, focusing on echocardiographic measurements to assess RA active emptying fraction (EaF) and RV fractional area change (FAC).
- Results indicated that specific RA and RV metrics, particularly RA EaF ≥60% and RVFAC <25%, are strong indicators of clinical worsening and mortality, suggesting their potential as important monitoring tools for affected children.
Background: Continuous intravenous epoprostenol was the first treatment approved for pulmonary arterial hypertension (PAH) but administration through a central venous line carries risks of thrombosis and sepsis, particularly in children. We sought to evaluate the safety, efficacy and management of subcutaneous (SC) treprostinil in children with PAH.
Methods: Fifty-six children (median age 65, range 1-200 months) were treated with SC treprostinil.
Article Synopsis
- - In a study of children with pulmonary hypertension (PH), researchers tested how breathing high concentrations of oxygen (FiO > 0.85) affects oxygen consumption (VO), challenging the belief that VO remains constant in hyperoxic conditions.
- - They analyzed hemodynamic data from 24 patients who underwent cardiac catheterization, finding significant decreases in VO, heart rate, cardiac index (CI), and pulmonary vascular resistance when subjects breathed hyperoxic air compared to room air.
- - The results showed that hyperoxia not only decreased VO and CI but also caused pulmonary vasodilation (widening of blood vessels in the lungs) and systemic vasoconstriction (narrowing of blood vessels throughout the body) in children with
We hypothesized that an automated speech- recognition-inspired classification algorithm could differentiate between the heart sounds in subjects with and without pulmonary hypertension (PH) and outperform physicians. Heart sounds, electrocardiograms, and mean pulmonary artery pressures (mPAp) were recorded simultaneously. Heart sound recordings were digitized to train and test speech-recognition-inspired classification algorithms.
View Article and Find Full Text PDFA 3-day-old neonate presented with features suggestive of coarctation of aorta. Echocardiography showed a large organized thrombus in the transverse arch causing obstruction to theaortic arch and carotids with partial recanalization. Patient underwent surgical thromboendarterectomy with arch reconstruction.
View Article and Find Full Text PDFWe report the successful transcatheter closure of right pulmonary artery fistula to left atrium in a six-year-old boy, who had presented with cyanosis and shortness of breath. The two-dimensional echocardiogram with bubble contrast study demonstrated the communication between right pulmonary artery and left atrium. Computerized tomography confirmed the diagnosis and delineated the anatomy.
View Article and Find Full Text PDFWe report a successful perventricular closure of an apical muscular ventricular septal defect (mVSD) by a modified technique. An eight-month-old infant, weighing 6.5 kilograms, presented with refractory heart failure.
View Article and Find Full Text PDFBackground: Surgical or transcatheter closure of muscular ventricular septal defects (mVSDs) in young children may be technically challenging and associated with significant complications.
Objective: To assess the feasibility of trans-septal antegrade closure of mVSD in a selected subset of young children.
Methods: This is a prospective study from a single centre from July 2011 to March 2013.