Application of a Web-Enabled Leg Training System for the Objective Monitoring and Quantitative Analysis of Exercise-Induced Fatigue.

Background: Sustained cardiac rehabilitation is the key intervention in the prevention and treatment of many human diseases. However, implementation of exercise programs can be challenging because of early fatigability in patients with chronic diseases, overweight individuals, and aged people. Current methods of fatigability assessment are based on subjective self-reporting such as rating of perceived exertion or require specialized laboratory conditions and sophisticated equipment.

Automated Management of Exercise Intervention at the Point of Care: Application of a Web-Based Leg Training System.

Background: Recent advances in information and communication technology have prompted development of Web-based health tools to promote physical activity, the key component of cardiac rehabilitation and chronic disease management. Mobile apps can facilitate behavioral changes and help in exercise monitoring, although actual training usually takes place away from the point of care in specialized gyms or outdoors. Daily participation in conventional physical activities is expensive, time consuming, and mostly relies on self-management abilities of patients who are typically aged, overweight, and unfit.

Development of the Internet-Enabled System for Exercise Telerehabilitation and Cardiovascular Training.

Objective: Sustained exercise training could significantly improve patient rehabilitation and management of noncommunicable diseases in the community. This study aimed to develop a universal telecare system for delivery of exercise rehabilitation and cardiovascular training services at home.

Materials And Methods: An innovative bilateral leg training device was equipped with an electronic system for the ongoing measurement of training activities with the device.

A bilateral rehabilitation system for the lower limbs.

Purpose: Bilateral and unilateral training equipment for the upper limbs facilitates rehabilitation after stroke. In this work, we tested the first device designed for bilateral training of the lower limbs.

Method: Characteristics and usage of the novel MedExercise® ST device were evaluated by four healthy volunteers.

Hypoxia causes aggregation of serine palmitoyltransferase followed by non-apoptotic death of human lymphocytes.

In the central nervous system chronic hypoxia has been suggested to cause neurodegenerations and protein aggregation, as in Alzheimer's disease. Here we have shown protein aggregation during acute hypoxia in human primary cells. Clinically relevant acute hypoxia (pO(2) = 25 mmHg) was produced by incubation of venous blood in vitro, where 18-hour incubation resulted in raise of pCO(2) to 90 mmHg, accumulation of lactate and acidosis (pH 7.

Equilibrium between cell division and apoptosis in immortal cells as an alternative to the G1 restriction mechanism in mammalian cells.

Starvation arrests cultured mammalian cells in the G(1) restriction point of the cell cycle, whereas cancer cells generally lose the regulatory control of the cell cycle. Human lymphocytes, infected with Epstein-Barr virus (EBV), also lose their cell cycle control and produce immortal lymphoblastoid cell lines. We show that during starvation, EBV-lymphoblasts override the cell cycle arrest in the G(1) restriction point and continue cell division.

Activity of partially inhibited serine palmitoyltransferase is sufficient for normal sphingolipid metabolism and viability of HSN1 patient cells.

Hereditary sensory neuropathy type I (HSN1) is a common degenerative disorder of peripheral sensory neurons. HSN1 is caused by mutations in the gene, encoding the long chain base 1 of serine palmitoyltransferase (SPT) [Nat. Genet.

Gingerols: a novel class of vanilloid receptor (VR1) agonists.

1. Gingerols, the pungent constituents of ginger, were synthesized and assessed as agonists of the capsaicin-activated VR1 (vanilloid) receptor. 2.

Cofilin and DNase I affect the conformation of the small domain of actin.

Cofilin binding induces an allosteric conformational change in subdomain 2 of actin, reducing the distance between probes attached to Gln-41 (subdomain 2) and Cys-374 (subdomain 1) from 34.4 to 31.4 A (pH 6.