Publications by authors named "Vadakepat Padmesh"
Background: Although therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy in low-income and middle-income countries is unclear. We aimed to examine whether therapeutic hypothermia alongside optimal supportive intensive care reduces death or moderate or severe disability after neonatal encephalopathy in south Asia.
Methods: We did a multicountry open-label, randomised controlled trial in seven tertiary neonatal intensive care units in India, Sri Lanka, and Bangladesh.
Article Synopsis
- A new diagnostic test using whole blood gene analysis may help identify encephalopathic babies at risk of poor neurodevelopmental outcomes within 18 months after birth.
- Researchers performed next-generation sequencing on blood samples from 45 encephalopathic infants, identifying 855 genes with significant differences between those with good and adverse outcomes.
- The findings suggest that transcriptomic profiling could enhance risk assessment in neonatal encephalopathy and reveal potential new treatments for protecting brain health.