Exosome-based drug delivery systems for enhanced neurological therapeutics.

Exosomes are small extracellular vesicles naturally secreted by cells into body fluids, enriched with bioactive molecules such as RNAs, proteins, and lipids. These nanosized vesicles play a crucial role in physiological and pathological processes by facilitating intercellular communication and modulating cellular responses, particularly within the central nervous system (CNS). Their ability to cross the blood-brain barrier and reflect the characteristics of their parent cells makes exosomal cargo a promising candidate for biomarkers in the early diagnosis and clinical assessment of neurological conditions.

Enhanced skin cancer diagnosis using optimized CNN architecture and checkpoints for automated dermatological lesion classification.

Skin cancer stands as one of the foremost challenges in oncology, with its early detection being crucial for successful treatment outcomes. Traditional diagnostic methods depend on dermatologist expertise, creating a need for more reliable, automated tools. This study explores deep learning, particularly Convolutional Neural Networks (CNNs), to enhance the accuracy and efficiency of skin cancer diagnosis.

Enhancing brain tumor detection in MRI images through explainable AI using Grad-CAM with Resnet 50.

This study addresses the critical challenge of detecting brain tumors using MRI images, a pivotal task in medical diagnostics that demands high accuracy and interpretability. While deep learning has shown remarkable success in medical image analysis, there remains a substantial need for models that are not only accurate but also interpretable to healthcare professionals. The existing methodologies, predominantly deep learning-based, often act as black boxes, providing little insight into their decision-making process.

Cyfra 21.1: A Useful Tumour Marker in Pancreatic Ductal Adenocarcinoma: Cross-Sectional Study.

Background: Pancreatic cancer is a challenging disease, often requiring invasive procedures for diagnosis. Reliable tumour markers are essential for ensuring early detection and better patient outcomes. Although Carbohydrate Antigen 19-9 is the most commonly used marker, it is marred by low predictive accuracy and high false positivity.

Diagnostic utility of point of care ultrasound in identifying cervical spine injury in emergency settings.

Introduction: The evaluation of cervical-spine in a major trauma patient needs a bedside efficient tool to rule out cervical spine injury as the role of X-ray and Computed Tomography (CT) in this setting is limited. Point of care ultrasonography (POCUS) is being used as an adjunct during trauma resuscitation. The aim of this study was to evaluate the use of POCUS for identifying cervical spine injuries.

First report of stem smut caused by Tranzscheliella hypodytes (Schltdl.) Vanky & McKenzie on Leymus secalinus (Georgi) Tzvelev in India.

Leymus secalinus (Blue wild rye) is a perennial grass species distributed in Leh-Ladakh region of India. Culms are usually solitary, 20-100 cm tall, 2-5-noded, smooth and glabrous. It is found on mountain slopes, rocky, stony and pebbled soils, grassy places, river banks, sandy and alkaline soils.

Rapid visible-light degradation of EE2 and its estrogenicity in hospital wastewater by crystalline promoted g-CN.

Metal-free, chemically activated crystalline graphitic carbon nitride (g-CN) nanorods with enhanced visible-light photoactivity demonstrated rapid photodegradation of 17α-ethinylestradiol (EE2) in water and real hospital wastewater. Pure g-CN and another three crystalline promoted g-CN photocatalysts developed by hydrothermal method were characterized by, High-Resolution Transmission Electron Microscopy (HRTEM), X-ray diffraction (XRD), Fourier-Transform Infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), Photoluminescence (PL), Electron spin resonance (ESR), X-ray Photoelectron Spectroscopy (XPS) and Diffuse Reflectance Spectroscopy (DRS). Hydrothermal-based chemical activation did not alter the crystal structure, functional group or surface morphology, but it enhanced the specific surface area of activated g-CN due to intralayer delamination and depolymerization of g-CN.

Molecular footprint of from India: a vector of Tospoviruses.

The western flower thrips, is a vector of Tospoviruses and native to Western North America and Mexico. The present study is based on collected specimens from Karnataka state in southern India and morphologically identified through available keys. The generated DNA barcode data show 99-100% similarity with the database sequences of .

Correction: Evaluation of 19,460 Wheat Accessions Conserved in the Indian National Genebank to Identify New Sources of Resistance to Rust and Spot Blotch Diseases.

[This corrects the article DOI: 10.1371/journal.pone.

Evaluation of 19,460 Wheat Accessions Conserved in the Indian National Genebank to Identify New Sources of Resistance to Rust and Spot Blotch Diseases.

A comprehensive germplasm evaluation study of wheat accessions conserved in the Indian National Genebank was conducted to identify sources of rust and spot blotch resistance. Genebank accessions comprising three species of wheat-Triticum aestivum, T. durum and T.

Expression of CD34 and CD68 in peripheral giant cell granuloma and central giant cell granuloma: An immunohistochemical analysis.

Background: Central and Peripheral giant cell granulomas of jaws are uncommon, benign, reactive disorders that are characterized by the presence of numerous multinucleated giant cells and mononuclear cells within a stroma. The origin of the multinucleated giant cells is controversial; probably originating from fusion of histiocytes, endothelial cells and fibroblasts.

Objective: To assess the expression of CD34 and CD68 in central and peripheral giant cell granulomas to understand the origin of these multinucleated giant cells.

Early and mid-term angiographic and clinical results after intracoronary duet stent placement.

The Duet stent (Guidant/Advanced Cardiovascular Systems) is a new stent with a corrugated ring design and very limited data on its short- and mid-term performance. Accordingly, in this study we sought to determine the early and mid-term clinical and angiographic outcomes in a moderate-sized series of 86 consecutive patients who underwent placement of 108 premounted Duet stents in 98 coronary lesions. Procedural success, accomplished in all patients, was accompanied by a significant reduction in lesion severity from 89% +/- 11% before to 5% +/- 3% diameter stenosis after the procedure (P = 0.