Time, dose and fractionation factor as an indicator of fibrosis of the abdominopelvic subcutaneous tissue.

Ninety-six patients treated with irradiation for epidermoid carcinoma of the uterine cervix were evaluated for the occurrence of subcutaneous tissue fibrosis of the hypogastrium. They were retrospectively stratified according to time, dose and fractionation (TDF) factors of the subcutaneous tissue, total dose delivered and treatment techniques. In our study only the TDF value of the subcutaneous tissue was unequivocally related to the occurrence of fibrosis.

[Effect of irradiation and heat on the agglutination and mitogenic capacity of phytohemagglutinins].

The authors studied the effect of ionizing radiation on hemaglutinating and mitogenic activity of phytohemaglutinis (PHA) in solution. 10 Krad (electron beam) are needed for the destruction of 50% of the aglutinating capacity. The mitogenic effect is more resistent to irradiation (70 Krad for 50% inactivation) maybe because both effects are due to different molecules.