Dual anti-CTLA-4 and anti-PD-1 blockade in metastatic basal cell carcinoma.

We report the basal cell cancer (BCC) cohort of the SWOG/NCI 1609 Dual Anti-CTLA-4 & Anti-PD-1 blockade in Rare Tumors (DART), a phase II prospective, multicenter basket trial of nivolumab and ipilimumab. The primary endpoint was objective response rate (ORR) (RECIST v1.1).

Bibliometric Analysis of Research on Lip Prints.

Lip prints, or cheiloscopy, are unique patterns of grooves and wrinkles, gaining prominence in forensic science as reliable tools for personal identification, akin to fingerprints and DNA profiling. Advances in imaging techniques have enhanced their forensic applicability. This study conducts a bibliometric analysis to explore global research trends, key contributors, and thematic developments in lip print research.

Elemental Analysis of a Nickel-Titanium (Ni-Ti) Pediatric Rotary File Coated With Graphene Oxide: An Energy Dispersive X-ray Analysis.

Background: Graphene oxide (GO) coatings have emerged as a promising method to enhance materials' surface properties and mechanical performance. In the context of endodontic files, the efficacy of these instruments is critically dependent on the properties of their outermost layer. Surface treatments and coatings can substantially improve these characteristics.

Predictive modeling of gestational weight gain: a machine learning multiclass classification study.

Background: Gestational weight gain (GWG) is a critical factor influencing maternal and fetal health. Excessive or insufficient GWG can lead to various complications, including gestational diabetes, hypertension, cesarean delivery, low birth weight, and preterm birth. This study aims to develop and evaluate machine learning models to predict GWG categories: below, within, or above recommended guidelines.

Antibiotic prescribing patterns in pediatric patients using the WHO access, watch, reserve (AWaRe) classification at a quaternary hospital in Nampula, Mozambique.

Antibiotics are often prescribed inappropriately, either when they are not needed or with an unnecessarily broad spectrum of activity. This is a serious problem that can lead to the development of antimicrobial resistance (AMR). This study was conducted to assess the antibiotic prescribing pattern in pediatric patients hospitalized at a quaternary hospital in Nampula, Mozambique, using the WHO indicators and Framework as a reference.

Surface Coating of Nickel-Titanium (Ni-Ti) Pediatric Rotary File Using Graphene Oxide: A Scanning Electron Microscopy Analysis.

Background: The effectiveness of endodontic files relies significantly on the characteristics of the outermost layer, which can be greatly improved through suitable surface treatments and appropriate coatings. Graphene-based materials (GBMs) have been utilized to fabricate nanocomposite coatings aimed at improving surface characteristics and mechanical behavior, including resilience, sustainability, oxidation resistance, solidity, and traction.

Aim: This research aims to study the surface topography of a nickel-titanium (Ni-Ti) pediatric rotary file coated with graphene oxide (GO) using a scanning electron microscope (SEM).

Atypical Aslanger pattern in inferolateral myocardial infarction - A new variant to look out for?

We report a case of a 53-year-old male with inferolateral myocardial infarction, presenting an atypical Aslanger pattern on electrocardiogram (ECG). The ECG showed ST elevation in leads III, aVR, aVF, and posterior leads, with ST depression in II and V2-V6 with terminal positive T waves. Coronary angiography revealed total occlusion of the left circumflex artery (LCx) with significant stenosis of the left anterior descending (LAD) and right coronary artery (RCA).

Predictors of inadequate gestational weight gain according to iom recommendations and intergrowth-21st standards: the araraquara cohort study.

Background: Gestational weight gain (GWG) is a critical factor for maternal and fetal health.

Objective: To identify maternal predictors of inadequate GWG according to the 2009 Institute of Medicine (IOM) recommendations and Intergrowth-21st standards.

Methods: A prospective epidemiological cohort study conducted from 2017 to 2023 in southeastern Brazil assessed 1,557 women at three different stages of pregnancy (≤ 18, 20-26, and 30-36 weeks of gestation) and at delivery.

Investigation of Oral Shedding of Torquetenovirus (TTV) in Moderate-to-Severe COVID-19 Hospitalised Patients.

Background: Torquetenovirus (TTV) is a small DNA virus constituting the human virome. High levels of TTV-DNA have been shown to be associated with immunosuppression and inflammatory chronic disorders.

Aim: To assess the possible association between the salivary viral load of TTV-DNA in patients hospitalised due to COVID-19 and disease severity.

The impact of gestational weight gain on fetal and neonatal outcomes: the Araraquara Cohort Study.

Background: Gestational weight gain (GWG) is an important indicator for monitoring maternal and fetal health.

Objective: To evaluate the effect of GWG outside the recommendations of the Institute of Medicine (IOM) on fetal and neonatal outcomes.

Study Design: A prospective cohort study with 1642 pregnant women selected from 2017 to 2023, with gestational age ≤ 18 weeks and followed until delivery in the city of Araraquara, Southeast Brazil.

Social Inequalities in Child Development: Analysis of Low-Birth-Weight Trends in Brazil, 2010-2020.

Introduction: Low birth weight (LBW) is a global issue prevalent in low-income countries. Economic assessments of interventions to reduce this burden are crucial to guide health policies. However, there is a relative scarcity of research that illustrates the magnitude of LBW by country and region to support the design of public policies.

Predictors of nutritional recovery time in children aged 6-59 months with severe acute malnutrition in Sofala Province, Mozambique: survival analysis approach.

Background: Malnutrition is a public health problem that affects physical and psychosocial well-being. It manifests as a rapid deterioration in nutritional status and bilateral edema due to inadequate food intake or illness.

Methods: This study is a retrospective cohort of 1208 children with severe acute malnutrition (SAM) in Sofala Province from 2018 to 2022.

Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model.

Hepatic xenobiotic metabolism and transport decline with age, while intact xenobiotic metabolism is associated with longevity. However, few studies have examined the genome-wide impact of epigenetic aging on these processes. We used reduced representation bisulfite sequencing (RRBS) to map DNA methylation changes in liver DNA from mice ages 4 and 24 months.

Effectiveness of Millet-Pulse-Groundnut Based Formulations in Improving the Growth of Pre-School Tribal Children in Telangana State, India.

A community-level nutritional intervention was implemented among tribal children (3 to 6 years of age) in Telangana, India. The one-year intervention involved six nutrient-rich formulations of millet-pulse-groundnut-based products suited to local taste preferences. Anthropometric measurements of height, weight, and mid-upper-arm circumference (MUAC) along with haemoglobin (Hb) levels were monitored at baseline and endline.

The role of cadre in the community on diabetic retinopathy management and its challenges in low-middle income countries: a scoping review.

Introduction: Diabetes is a serious public health problem, with low- and middle-income countries (LMICs) bearing over 80% of the burden. Diabetic retinopathy (DR) is one of the most prevalent diabetic microvascular problems, and early diagnosis through eye screening programs for people with diabetes is critical to prevent vision impairment and blindness. Community-based treatments, including non-physician cadres have been recommended to enhance DR care.

Analysis of DWT-DCT watermarking algorithm on digital medical imaging.

Purpose: Over the past decade, the diagnostic information of the patients are digitally recorded and transferred. During the transmission of patients data, the security and authenticity of the information has to be ensured. Medical image watermarking technology has recently advanced because it can be used to conceal patient information while ensuring the authenticity.

Analysis of computational intelligence approaches for predicting disease severity in humans: Challenges and research guidelines.

The word disease is a common word and there are many diseases like heart disease, diabetes, breast cancer, COVID-19, and kidney disease that threaten humans. Data-mining methods are proving to be increasingly beneficial in the present day, especially in the field of medical applications; through the use of machine-learning methods, that are used to extract valuable information from healthcare data, which can then be used to predict and treat diseases early, reducing the risk of human life. Machine-learning techniques are useful especially in the field of health care in extracting information from healthcare data.

The experience of diagnosis announcement in rare endocrine diseases: A survey of the French FIRENDO network.

Context: Diagnosis announcement of a chronic disease is a crucial moment for patients as well as for their families and an important step in the management of severe conditions such as rare endocrine diseases. Little is known of how diagnosis is communicated to patients and families. The FIRENDO network was created by the third French Plan for Rare Diseases, to promote autonomy, care and research on rare endocrine diseases.

A Variant of Unknown Significance in a Patient With a Cardiac Functional Paraganglioma.

Cardiac paragangliomas are extremely rare tumors derived from chromaffin cells of the neural crest. Succinate dehydrogenase B () mutations are associated with metastatic potential and potentially worse prognosis. Here we describe the case of a 64-year-old man who presented with chest pain, fatigue, and weight loss.

Comparison of micropulse subthreshold laser plus anti-VEGF versus anti-VEGF alone in diabetic macular edema: Systematic review.

Intravitreal injection of anti- Vascular Endothelial Growth Factor (VEGF)is commonly used to treat patients with diabetic macular edema (DME). However, the injection alone requires high cost and compliance. Combining micropulse subthreshold laser (MPSL) and anti-VEGF is a new approach to treating DME.

Efficacy of Prophylactic Anti-VEGF in Preventing Radiation Retinopathy: A Systematic Review and Meta-Analysis.

Background: In patients predisposed to radiation retinopathy (RR), administration of therapy after apparent clinical signs and symptoms are considered too late, resulting in substantial vision loss and blindness. Early initiation of anti-vascular endothelial growth factor (anti-VEGF) might serve as a strategy to slow disease progression and prolong good eyesight.

Objective: To evaluate the efficacy of prophylactic anti-VEGF in preventing RR and preserving vision in patients at high risk of radiation-induced vision loss.

Recurrence risk of myopic choroidal neovascularisation: a systematic review of current study.

Introduction: The rising prevalence of myopia is a concern in ophthalmology, with myopic choroidal neovascularisation (m-CNV) significantly affecting vision. However, long-term outcomes of m-CNV management have been unsatisfactory, leading to high recurrence rates. These studies aim to identify risk factors for m-CNV recurrence.