[Computerized quantitative topo-electroencephalography].

A method is described which has been developed to topographically display the values of spectral EEG analysis from 11 electrodes on each hemisphere and 5 electrodes on the midline. The EEG from 16 channels at a time is multiplexed and sampled at 3.2 kHz.

[Topographic aspects of drug-induced fast rhythms in quantitative topo-electroencephalography].

The topographical aspects of fast rhythms induced by different psychotropic drugs have been studied in patients by means of a previously described method. This method is based on the spectral analysis of 28 EEG channels over both cerebral hemispheres. The spectral parameters, computed over 2 min 40 sec, are put into a data base.

[Multivariate correspondence analysis of a visually screened EEG. Application to a study of psychotropic drugs compared with placebos (author's transl)].

Eighty-seven EEG recordings were obtained from 9 healthy volunteers, medical students who were part of a controlled, double-blind, randomized study. After a first control recording, they received orally, at 1 week interval, either 3 placebos or 3 compounds: yohimbine chlorhydrate (4 mg), propranolol (40 mg), a psychotropic compound in experimentation. The polygraphic recordings were obtained 2 or 6 h after placebos or active compounds.

Intra- and interhemispheric EEG differences quantified by spectral analysis. Comparative study of two groups of schizophrenics and a control group.

In this work we have studied comparatively the relationships between alpha intensity, alpha frequency, root-mean-square amplitude and their standard deviations, versus the location of the four recorded EEG channels: left and right rolando-parietal, left and right parieto-occipital. Twenty-four spectral parameters were computed for each 5-min EEG recording, in the eyes closed situation. The hebephrenic group (36 EEGs from six patients) presented higher values of alpha intensity and RMS amplitudes with low coefficient of variation when compared with the other groups.

[Statistical spectral study of alpha rhythms: modifications due to the tardive action of a hypnotic (author's transl)].

In a simple blind study to evaluate electroencephalographic criteria objectively, and to continue characterization of psychotropic compounds, 5 mg of nitrazepam, a hypnotic derivative, was given to seven subjects the night before the recording. We noted that in most subjects there was a reduction in the spectral intensity of the alpha rhythm, associated with a greater frequency instability, several hours after the absorption of nitrazepam. This corresponds to the tardive hypnotic action of the psychotrope, the importance of which is wellknown at the present time.

[Alpha activity in a group of schizophrenics: spectral analysis and comparison with a control group (author's transl)].

Spectral analysis of tracings from four leads; C3-P3, P3-O1, C4-P4, and P4-O2, were used to compare the results of fiftyseven electroencephalograms from 10 schizophrenics, and 14 normal subjects used as controls. The results show that the mean frequencies of the alpha waves are identical in schizophrenics and controls. Patients with hebephrenia show the lowest variations in alpha wave frequency but with the highest voltage, whereas paranoid schizophrenics have tracings with the lowest amplitude and the greatest variation in frequency.

[Relationship between blood zinc level and EEG changes under the influence of hyperpnea in normal subjects].

The red blood cell and serum zinc levels have been determined by atomic absorption spectrophotometry on 27 human subjects in apparent good state of health, tested monthly for five months successively. The subjects who present a decreased frequency of the E.E.

[A new psychotropic drug: carpipramine, intermediate compound between 2 therapeutic classes].

An open clinical study was conducted with carpipramine in 100 hospitalized subjects presenting various mental disorders. The therapeutic results on symptoms were assessed both as a whole and with the help of a rating scale. Doses varied from 50 to 400 mg per day.

[Clinical and electroencephalographic study of a new antidepressive agent, mono-methyl-amino-propyl-dibenzo-bicyclo-octadine hydrochloride (Ciba 34, 276 Ba)].

A clinical trial on fifty patients studied a new compound with a quadricyclic structure, Ciba 34.276-Ba or Maprotiline in any category of depression. The product was found to have notable antidepressive properties, capable to act on the melancholic depressions of the manic depressive psychosis and of involutive melancholia.