Adherence to CPAP with a nasal mask combined with mandibular advancement device versus an oronasal mask: a randomized crossover trial.

Purpose: Evidence for the management of CPAP-treated obstructive sleep apnea suggests that oronasal masks reduce mouth leaks at the expense of higher pressures and poorer adherence. Some authors have proposed the use of mandibular advancement devices in combination with nasal masks to address this. The aim of this study was to assess adherence to CPAP after 1 month's use of a nasal mask with a mandibular advancement device and to compare adherence with an oronasal mask.

Sex differences in mandibular repositioning device therapy effectiveness in patients with obstructive sleep apnea syndrome.

Purpose: Mandibular repositioning devices (MRDs) are an effective treatment option for obstructive sleep apnea syndrome (OSAS), particularly in patients who refuse or cannot tolerate continuous positive airway pressure (CPAP). However, sex differences in the response to therapy and predictors of response are not clearly defined. This analysis of data from the long-term prospective ORCADES trial compared MRD efficacy in men and women with OSAS.

[The therapeutic utilization of magnesium: medical consequences].

To optimize a pharmaceutical formulation, one has to take into account physicochemical, biopharmaceutical, therapeutical and technological properties of the active principle. These properties are investigated in the PREFORMULATION phase. The authors envisage dosage form (capsule) of magnesium and describe two aspects of the active principle: therapeutic and biopharmaceutic.

[The bioavailability of paracetamol II. The effect of porosity and mechanical properties of the dosage form on solubility].

The authors attempt to explain differences observed in dissolution rate of twelve different brands of paracetamol (nine tablets and three capsules) in terms of pore structure and tensile strength; the pore structure of both tablets and capsules is investigated by mercury porosimetry. Brands (tablets) which liberate paracetamol rapidly are characterized by a higher porosity value. Higher mean pore diameter signifies less t50 and higher porosity.

[The biodisposition of paracetamol. I. The kinetics of disintegration of some dosage forms].

The in vitro properties of twelve brands of paracetamol (nine tablets and three capsules), commercialized in France, are studied. Among the brands tested (tablets), Latepyrine and Gynospasmine are characterized by faster and Panasorb by slower dissolution rate. Total time of dissolution varies between 7 and 60 min.

[Pharmaceutical engineering in drug formulation].

The industrial pharmacist, a "pharmaceutical engineer"? The prospect is tempting if only beneficial to drug quality. The Pharmaceutical Engineering comes from Chemical Engineering and Engineer sciences and allows the pharmacist to achieve his aim. We define here the basis of this recent concept, its intervention and interest in the pharmaceutical sciences, more particularly in formulation.

Cyst formation in gastric heterotopic pancreas: report of two cases.

Cyst formation is an uncommon pathologic finding in heterotopic pancreas. It is sometimes reported in a duodenal location but very rarely in a gastric location and leads to very large lesions of unusual endoscopic and radiographic appearance. Two cases of gastric heterotopic pancreas are described in which cystic zones in the gastric wall were found at preoperative ultrasound or computed tomography.