Chemotaxonomy and Bioactive Potential of High-Mountain Plantago atrata.

Plantago atrata Hoppe is a high-altitude mountain plant exposed to harsh environmental factors. This study aims to elucidate the ecological, phytochemical and pharmacological characteristics of this lesser-known plantain. Despite nutrient-poor peat soil, the leaves of P.

How Histone Acetyltransferases Shape Plant Photomorphogenesis and UV Response.

Higher plants have developed complex mechanisms to adapt to fluctuating environmental conditions with light playing a vital role in photosynthesis and influencing various developmental processes, including photomorphogenesis. Exposure to ultraviolet (UV) radiation can cause cellular damage, necessitating effective DNA repair mechanisms. Histone acetyltransferases (HATs) play a crucial role in regulating chromatin structure and gene expression, thereby contributing to the repair mechanisms.

Cytokinins enhance the metabolic activity of in vitro-grown catmint (Nepeta nuda L.).

The phytohormones cytokinins are essential mediators of developmental and environmental signaling, primarily during cell division and endophytic interactions, among other processes. Considering the limited understanding of the regulatory mechanisms that affect the growth and bioactivity of the medicinal plant Nepeta nuda (Lamiaceae), our study aimed to explore how cytokinins influence the plant's metabolic status. Exogenous administration of active cytokinin forms on in vitro N.

Neuroprotective Effect of Extract in Scopolamine-Induced Cognitive Impairment in Rats: Behavioral and Biochemical Approaches.

The potential of to alleviate scopolamine (Sco)-induced deficits in spatial working memory has drawn considerable scientific interest. This effect is partly attributed to its potent antioxidant and acetylcholinesterase inhibitory (AChEI) activities. This study examined the effects of extract, standardized to marrubiin content, on recognition memory in healthy and Sco-treated rats.

Extracts of and Alleviate Cognitive Impairments in Scopolamine-Induced Rat Dementia.

Griseb. and L., belonging to the Lamiaceae family, are rich in terpenoids and phenolics and exhibit various pharmacological effects, including antioxidant, anti-inflammatory and anti-cancer activities.

Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants.

The family of Nuclear Distribution C (NudC) proteins plays a pivotal and evolutionarily conserved role in all eukaryotes. In animal systems, these proteins influence vital cellular processes like cell division, protein folding, nuclear migration and positioning, intracellular transport, and stress response. This review synthesizes past and current research on NudC family members, focusing on their growing importance in plants and intricate contributions to plant growth, development, and stress tolerance.

Uncovering the Interrelation between Metabolite Profiles and Bioactivity of In Vitro- and Wild-Grown Catmint ( L.).

L. is a medicinal plant enriched with secondary metabolites serving to attract pollinators and deter herbivores. Phenolics and iridoids of have been extensively investigated because of their beneficial impacts on human health.

Study on Hardness of Heat-Treated CoCrMo Alloy Recycled by Electron Beam Melting.

The hardness of heat (thermally) treated CoCrMo ingots, recycled by electron beam melting and refining (EBMR) of a technogenic CoCrMo material (waste from the dental technology) under different process conditions (temperature and residence time) is examined. The heat treatment consists of two-step heating up to temperatures of 423 K and 1343 K and retention times of 40 and 60 min, respectively. The influence of various loads (0.

Stress Management in Plants: Examining Provisional and Unique Dose-Dependent Responses.

The purpose of this review is to critically evaluate the effects of different stress factors on higher plants, with particular attention given to the typical and unique dose-dependent responses that are essential for plant growth and development. Specifically, this review highlights the impact of stress on genome instability, including DNA damage and the molecular, physiological, and biochemical mechanisms that generate these effects. We provide an overview of the current understanding of predictable and unique dose-dependent trends in plant survival when exposed to low or high doses of stress.

Study of the Possibility of Recycling of Technogenic Hafnium during Electron Beam Refining.

The possibility of removing metallic (such as Zr, Fe, Cr, and Zn) impurities and non-metallic (such as [O] and C) impurities from technogenic hafnium through single and double refining in the conditions of electron beam melting (EBM) has been studied. The influence of thermodynamic and kinetic parameters on the degree of removal of these impurities from the base metal under vacuum conditions and within a temperature interval of 2500 K to 3100 K is defined. The relative volatility of metal impurities and the stability of the oxides and carbides present in the base metal are evaluated.

Jewel Orchid's Biology and Physiological Response to Aquaponic Water as a Potential Fertilizer.

is commonly known as a jewel orchid due to its variegated leaves. Easy maintenance of the orchid allows it to be used as a test system for various fertilizers and nutrient sources, including aquaponic water (AW). First, we applied DNA barcoding to assess the taxonomic identity of this terrestrial orchid and to construct phylogenetic trees.

Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance.

Over 80% of patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed at a late stage and are locally advanced or with concurrent metastases. The aggressive phenotype and relative chemo- and radiotherapeutic resistance of PDAC is thought to be mediated largely by its prominent stroma, which is supported by an extracellular matrix (ECM). Therefore, we investigated the impact of tissue-matched human ECM in driving PDAC and the role of the ECM in promoting chemotherapy resistance.

Recycling of Technogenic CoCrMo Alloy by Electron Beam Melting.

In the current work, the possibility of the recycling of technogenic CoCrMo material by electron beam melting is investigated. The influence of thermodynamic and kinetic parameters (temperature and melting time) on the behavior of the main components of the alloy (Co, Cr, and Mo) and other elements (Fe, Mn, Si, W, and Nb) present in it, and on the microstructure of the ingots obtained after e-beam processing is studied. The vapor pressure of the alloy is determined taking into account the activities of the main alloy components (Co, Cr, and Mo).

Catmint ( L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.

(catmint; Lamiaceae) is a perennial medicinal plant with a wide geographic distribution in Europe and Asia. This study first characterized the taxonomic position of using DNA barcoding technology. Since medicinal plants are rich in secondary metabolites contributing to their adaptive immune response, we explored the metabolic adjustment operating under variable environments.

Behaviour of Impurities during Electron Beam Melting of Copper Technogenic Material.

The current study presents the electron beam melting (EBM) efficiency of copper technogenic material with high impurity content (Se, Te, Pb, Bi, Sn, As, Sb, Zn, Ni, Ag, etc.) by means of thermodynamic analysis and experimental tests. On the basis of the calculated values of Gibbs free energy and the physical state of the impurity (liquid and gaseous), a thermodynamic assessment of the possible chemical interactions occurring in the Cu-CuO-Me system in vacuum in the temperature range 1460-1800 K was made.

Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.

To pinpoint ethylene-mediated molecular mechanisms involved in the adaptive response to salt stress we conducted a comparative study of Arabidopsis thaliana wild type (Col-0), ethylene insensitive (ein2-1), and constitutive signaling (ctr1-1) mutant plants. Reduced germination and survival rates were observed in ein2-1 plants at increasing NaCl concentrations. By contrast, ctr1-1 mutation conferred salt stress tolerance during early vegetative development, corroborating earlier studies.

Epigenetics for Crop Improvement in Times of Global Change.

Epigenetics has emerged as an important research field for crop improvement under the on-going climatic changes. Heritable epigenetic changes can arise independently of DNA sequence alterations and have been associated with altered gene expression and transmitted phenotypic variation. By modulating plant development and physiological responses to environmental conditions, epigenetic diversity-naturally, genetically, chemically, or environmentally induced-can help optimise crop traits in an era challenged by global climate change.

Effective Detection and Monitoring of Glioma Using [F]FPIA PET Imaging.

Background: Reprogrammed cellular metabolism is a cancer hallmark. In addition to increased glycolysis, the oxidation of acetate in the citric acid cycle is another common metabolic phenotype. We have recently developed a novel fluorine-18-labelled trimethylacetate-based radiotracer, [F]fluoro-pivalic acid ([F]FPIA), for imaging the transcellular flux of short-chain fatty acids, and investigated whether this radiotracer can be used for the detection of glioma growth.

Deciphering the Epigenetic Alphabet Involved in Transgenerational Stress Memory in Crops.

Although epigenetic modifications have been intensely investigated over the last decade due to their role in crop adaptation to rapid climate change, it is unclear which epigenetic changes are heritable and therefore transmitted to their progeny. The identification of epigenetic marks that are transmitted to the next generations is of primary importance for their use in breeding and for the development of new cultivars with a broad-spectrum of tolerance/resistance to abiotic and biotic stresses. In this review, we discuss general aspects of plant responses to environmental stresses and provide an overview of recent findings on the role of transgenerational epigenetic modifications in crops.

Neonicotinoid insecticides exert diverse cytotoxic and genotoxic effects on cultivated sunflower.

Contamination with neonicotinoids is a global problem affecting environment and target and non-target organisms including plants. The present study explored the potential genotoxic and cytotoxic effects of the insecticides Actara 25 WD and Nuprid 200 SL containing the active substances thiamethoxam (TMX) and imidacloprid (IMI), respectively, on cultivated sunflower (Helianthus annuus L.).

The Diverse Salt-Stress Response of Arabidopsis and Ethylene Signaling Mutants Is Linked to Altered Root Auxin Homeostasis.

We explored the interplay between ethylene signals and the auxin pool in roots exposed to high salinity using wild-type plants (Col-0), and the ethylene-signaling mutants (constitutive) and (insensitive). The negative effect of salt stress was less pronounced in individuals, which was concomitant with augmented auxin signaling both in the controls and after 100 mM NaCl treatment. The R2D2 auxin sensorallowed mapping this active auxin increase to the root epidermal cells in the late Cell Division (CDZ) and Transition Zone (TZ).

Overexpression of the Gene Encoding a NudC Domain Protein Enhances Root Growth and Abiotic Stress Tolerance in .

The family of NudC proteins has representatives in all eukaryotes and plays essential evolutionarily conserved roles in many aspects of organismal development and stress response, including nuclear migration, cell division, folding and stabilization of other proteins. This study investigates an undescribed homolog of the gene, named (for ), which shares high sequence similarity to other plant and mammalian -like genes. Expression of was highly upregulated in response to several abiotic stress factors, such as heat shock, drought and high salinity.

Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer.

Reprogrammed glucose metabolism is one of the hallmarks of cancer, and increased expression of key glycolytic enzymes, such as pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA), has been associated with poor prognosis in various malignancies. Targeting these enzymes could attenuate aerobic glycolysis and inhibit tumor proliferation. We investigated whether the PKM2 activator, TEPP-46, and the LDHA inhibitor, FX-11, can be combined to inhibit in vitro and in vivo tumor growth in preclinical models of pancreatic cancer.