MR appearance of the distended iliopsoas bursa.

The purpose of this essay is to illustrate the MR appearance of the distended iliopsoas bursa. The bursa must be recognized on MR scans to avoid confusing it with malignant neoplasms and other lesions.

Effects of protein-calorie malnutrition on transplacental kinetics of aminoisobutyric acid in rats.

In order to find out if inefficient transport of amino acids contributes to a decrease in fetal weight during maternal malnutrition, we injected [14C]- and [3H]-labelled aminoisobutyric acid (AIB), respectively, in the mother and its fetuses and determined its transplacental kinetics on day 20 of gestation in rats fed a 21 per cent (control) or a low (5 per cent) protein diet. Rats fed a low protein diet consumed significantly less food than did the rats fed a control diet and thus suffered from protein-calorie malnutrition. A low protein diet led to a significant (P less than 0.

Developmental toxicity of methylamines in mice.

Monomethylamine (MMA), dimethylamine (DMA), and trimethylamine (TMA) are endogenous substances as well as metabolites of methyl isocyanate, the chemical involved in the 1984 accident at Bhopal, India. Although methylamines exert several toxic effects including inhibition of protein turnover and oocyte RNA synthesis, their reproductive toxicity has not been investigated. We therefore studied the possible developmental toxicity of these amines using pregnant CD-1 mice and mouse embryo culture as experimental models.

Effects of cocaine on rat embryo development in vivo and in cultures.

Intraperitoneal injections of 6.25, 12.5, 25, 50, and 100 mumols/kg cocaine into pregnant Sprague-Dawley rats once a day from d 0 to 19 of gestation caused a dose-dependent increase in fetal soft tissue malformations, primarily of the genitourinary tract.

Case report 682. Neuroepithelioma of soft tissues of the knee.

Peripheral neuroepitheliomas should be included in the differential diagnosis of a soft-tissue tumor in the extremities or chest wall, especially in young adolescents. MRI provides useful information as to the extent of the tumor and relationship with adjacent structures, although it may not differentiate neuroepitheliomas from other, more common, soft-tissue sarcomas. Together with clinical and histological findings, MRI can assist in the diagnosis and treatment planning of this tumor.

College undergraduate drug use and life-styles, 1969, 1978 and 1989.

G SUBSTANCE ABUSE / * ep ENTS / * psychol INE HOL DRINKING / psychol BEHAVIOR

Ontogeny of responses of rabbit aorta to atrial natriuretic factor and isoproterenol.

Ontogeny of the vasorelaxant effects of atrial natriuretic factor (ANF) and isoprenaline and of the vasoconstrictor effects of potassium and phenylephrine were studied on aortic strips from rabbits aged 1, 2, 3, 6, 10 and 32-48 (adult) weeks. ANF caused complete relaxation of phenylephrine- and potassium-contracted aortic strips from all age groups of rabbits and its potency was not altered by age and by the agent used to cause contractions. On the other hand, the vasorelaxant efficacy and potency of isoproterenol decreased with age.

Changes in cerebrovascular prostaglandins and thromboxane as a function of systemic blood pressure. Cerebral blood flow autoregulation of the newborn.

Cerebrovascular concentrations of prostaglandin E (PGE), prostaglandin F2 alpha (PGF2 alpha), 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha), and thromboxane B2 (TXB2) were determined over a blood pressure range of 17-117 mm Hg (induced by inflation of balloon-tipped catheters placed in the thoracic descending aorta and at the aortic root) in eight newborn piglets to access the role of prostanoids in cerebral blood flow (CBF; measured using radioactive microspheres) autoregulation. Basal systemic blood pressure, heart rate, blood gases, total CBF, and prostanoid concentrations were stable. CBF was constant between 50 and 90 mm Hg, but beyond this range CBF varied directly with blood pressure (tau = 0.

Purification of rat pro-atrial natriuretic factor: a simplified scheme using reversed-phase high-performance liquid chromatography.

A simple scheme for the rapid and efficient isolation of rat pro-atrial natriuretic factor (pro-ANF) has been developed. An isolated rat adrenal cell bioassay for ANF was established to optimize heart tissue extraction and chromatography conditions. This assay is based on the ability of ANF to inhibit angiotensin II-stimulated aldosterone secretion.

Drug use and life style among college undergraduates in 1989: a comparison with 1969 and 1978.

The authors conducted anonymous questionnaire studies of drug use and life style among college seniors at the same institution in 1969, 1978, and 1989. The 1989 group of students reported strikingly lower frequencies of virtually all forms of drug use than their counterparts in 1969 and 1978. As in 1969 and 1978, the drug users among the 1989 group were indistinguishable from nonusers in grades, athletic activities, other college activities, and feelings of alienation.

Refractoriness of the gravid rat uterus to tocolytic and biochemical effects of atrial natriuretic peptide.

1. Effects of atrial natriuretic peptide (ANP) on tension development, particulate guanylate cyclase activity and guanosine 3':5'-cyclic monophosphate (cyclic GMP) concentrations of uteri from oestrogen-treated, progesterone-treated, ovariectomized and pregnant rats were determined in vitro. 2.

Dissociation between maternal and fetal toxicity of methyl isocyanate in mice and rats.

The contribution of maternal hormonal changes and pulmonary damage on the fetal toxicity of methyl isocyanate (MIC) was studied in mice and rats. Exposure to MIC decreased maternal plasma progesterone levels in mice that lost but not in mice that retained pregnancy. Fetal toxicity of MIC was not related to changes in maternal plasma corticosterone levels.

Prostanoids determine the range of cerebral blood flow autoregulation of newborn piglets.

To assess whether prostanoids have a role in setting the blood pressure limits of cerebral blood flow autoregulation in newborn animals, we measured cerebral blood flow and prostanoid concentrations in blood from the sagittal sinus over a wide range of mean systemic blood pressures (17-117 mm Hg) in eight newborn piglets treated with 30 mg/kg i.v. ibuprofen and in eight vehicle-treated piglets.

Magnetic resonance imaging of adult ovarian granulosa cell tumor. Case report.

We report the magnetic resonance imaging (MRI) findings in a unilocular multicystic adult granulosa cell tumor of the ovary. MRI, in conjunction with the clinical and laboratory findings, helped establish a preoperative diagnosis.

Effects of prostaglandins and indomethacin on cerebral blood flow and cerebral oxygen consumption of conscious newborn piglets.

The effects of the prostaglandins (PG) PGE1, PGE2, PGF2 alpha and PGI2, and of indomethacin on cerebral blood flow (CBF) and cerebral metabolic rate for O2 (CMRO2) were studied in 60 1- to 3-day-old conscious piglets. Effects of PGs in indomethacin-treated animals were also measured. CBF was measured by radiolabelled microspheres prior to and 45 s after intracarotid bolus injections of 0.

Effects of adenosine and its analogues on isolated internal carotid arteries from newborn and adult pigs.

Vasorelaxant effects of adenosine and its analogues, 5'-N-(ethylcarboxamide) adenosine (NECA), N6-(l-phenylisopropyl)-adenosine (l-PIA) and N6-cyclohexyladenosine (CHA), on isolated internal carotid arteries from newborn (1-3 days) and adult (6 months) pigs were compared. The order of vasorelaxant potencies of adenosines was: NECA greater than l-PIA greater than adenosine greater than CHA for the adult arteries and NECA greater than l-PIA greater than adenosine = CHA for the newborn arteries. Sensitivities of vessels from the newborn and mature animals to CHA and l-PIA did not differ.

Bronchodilator activity of atrial natriuretic peptide in guinea pigs.

Atrial natriuretic peptide (ANP) produced concentration-dependent relaxation of isolated guinea pig tracheal chains contracted with histamine, serotonin, carbachol, and arachidonic acid. ANP was a full agonist. ANP was two- to three-fold less potent when compared with isoprenaline in relaxing histamine-, serotonin-, and arachidonic acid-contracted tracheal chains.

Alternating sequential dosing with furosemide and ethacrynic acid in drug tolerance in the newborn.

Drug tolerance seems to develop rapidly after the administration of sequential doses of the same loop diuretic. We evaluated whether alternating different loop diuretics could achieve the same initial diuretic response in the newborn. In a randomized double crossover study, we examined the diuretic and saliuretic effects of alternating doses of furosemide and ethacrynic acid (1 mg/kg administered intravenously every 24 hours) in 10 newborns, who received the drugs in the following sequential order: (1) furosemide, (2) ethacrynic acid, and (3) furosemide (group 1, n = 5); and (1) ethacrynic acid (2) furosemide, and (3) ethacrynic acid (group 2, n = 5).

Selective increase in placental blood flow by atrial natriuretic peptide in hypertensive rats.

Effects of atrial natriuretic peptide on systemic, renal, uterine, and placental hemodynamics were determined in 16-day pregnant normotensive and hypertensive rats and in 20-day pregnant normotensive rats under pentobarbital anesthesia. Relative to 16-day pregnant normotensive rats, the total peripheral resistance was higher in 16-day pregnant hypertensive and 20-day pregnant normotensive rats; atrial natriuretic peptide significantly (p less than 0.05) decreased the total peripheral resistance in the latter two groups of animals.

Osler-Weber-Rendu disease: MR findings in the liver.

We report the magnetic resonance (MR) findings in the liver of a patient with known Osler-Weber-Rendu disease, a rare disorder characterized by arteriovenous malformations involving multiple organ systems. To the best of our knowledge, the MR findings in liver involvement have not been previously reported.