[Sexual differentiation of the adipose tissue-muscle ratio. Its metabolic impact].

Muscle and fat development are regulated by opposite and also cooperating factors. Adipo-muscular ratio is the result of those forces. The need of a determined fat mass and of its corollary a determined muscle mass is an important physiologic parameter.

Clinical features of diabetogenic and atherogenic obesity.

Fat mass per se has little effect on the progression of obesity towards diabetes. Predominance of fat in the upper part of the body resulting in android obesity is at least the clinical reflection of factors which lead obesity to progress towards diabetes and atherosclerosis. Therefore, this type of obesity may be termed diabetogenic and atherogenic obesity.

[Comparative study of adrenaline-induced lipolysis of human deltoid and trochanter adipose tissue].

In vitro lipolysis by adrenaline, adrenaline + phentolamine (alpha-blocker) and isoprenalin (beta-agonist) was studied in deltoid and trochanter adipose tissues of sixteen obese females (10 android and 6 gynoid). Lipolysis differs in the upper and lower parts of the body. The more the obesity predominates in the upper part of the body, the more this difference is significant.

[Hormones and aging. 2].

The main hormonal disturbances in ageing are: 1) a slight decrease in the secretion of all hormones, with the exception of gonadotropins in women whose production increases sharply as a result of the almost complete suppression of ovarian activity; 2) a slight but substantial resistance of tissues to the action of most hormones; 3) the cessation of estrogen secretion with an important decrease in androgen secretion in the ovaries; 4) a decrease in androgen secretion with a lesser reduction in estrogen secretion in the testicles; 5) an important decrease in adrenal androgen secretion in both sexes. These findings are the consequence and not the cause of ageing which, to some degree, they do promote, especially in bone, muscle, skin and mucous membranes. Therapeutic incidences of the hormonal disturbances in ageing, though not negligeable, are still limited.

[Hormones and aging, (1)].

The main hormonal disturbances in ageing are: a slight decrease in the secretion of all hormones, with the exception of gonadotropins in women whose production increases sharply as a result of the almost complete suppression of ovarian activity; a slight but substantial resistance of tissues to the action of most hormones; the cessation of estrogen secretion with an important decrease in androgen secretion in the ovaries; a decrease in androgen secretion with a lesser reduction in estrogen secretion in the testicles; an important decrease in adrenal androgen secretion in both sexes. These findings are the consequence and not the cause of ageing which, to some degree, they do promote, especially in bone, muscle, skin and mucous membranes. Therapeutic incidences of the hormonal disturbances in ageing, though not negligible, are still limited.

[Hypogonadism with spermatogenesis (fertile eunuch syndrome) (author's transl)].

Hypogonadism with spermatogenesis (fertile eunuch syndrome) occupies a special nosologic situation because of it's clinical and paraclinical features. These include: eunuchism of testosterone's target tissues, contrasting with clinically normal testes; normal embryonic male differentiation; low serum testosterone concentrations; moderately decreased or normal LH serum concentrations which are coincident with low testosterone levels therefore reflecting at least relative LH insufficiency; normal FSH levels; normal LHRH response; variable clomifen response; poor spermatogenesis improved by HCG and/or testosterone, and in some cases by HMG; atrophic leydig cells. Although in very rare instances it may include anosmia, the fertile eunuch syndrome should be clearly distinguished from complete FSH and LH deficiency with or without anosmia.

[Thyrotoxic periodic paralysis. Its nosographic situation].

Thyrotoxic Periodic Paralysis is a well-defined syndrome from the standpoint of clinical, electromyographic, biochemical, microscopic and etiologic features. The syndrome is characterized by acute episodes of flaccid para or tetraplegia induced by excess exogenous or endogenous thyroid hormones. This syndrome is distinct from thyrotoxic myopathy and familial periodic paralysis.

[Aromatization of androgens (author's transl)].

Aromatization of androgens into estrogens is an early phenomenon during phylogenesis and ontogenesis which occurs in most tissues. The mechanism which is responsible for this activity and for it's competition with 5 alpha reduction includes hypothalamo-pituitary receptors, genetic induction of sexual differentiation, binding proteins, and sulfo and glyco-conjugation. Aromatization is determinant before, during, and after ovulation, as well as in developing pregnancy.

[Non-hormonal therapy for menopausal disorders: results of a multicentric double-blind trial (author's transl)].

A multicentric trial was conducted under double-blind conditions to assess the efficacy of veralipride in the treatment of menopausal disorders, when compared with placebo. Excellent or good results were obtained in 32 of the 40 patients (80 p. cent) with sudden flushes, after veralipride treatment, and only 17 of the 35 patients (48,5 p.