The differing effects of acute and chronic alcohol on gastric and intestinal permeability.

Objective: Acute and chronic alcohol intake cause GI symptoms because of either alcohol-induced structural or functional abnormalities. In theory, the disruption of the integrity of the gut mucosa should be reflected by changes in the absorption of molecular probes, such as lactulose, mannitol, and sucrose. Accordingly, we investigated the effects of acute and chronic ethanol on the permeability of the gastric and small intestinal mucosa.

Attention deficits disorder and drug abuse.

Recent research studies have attempted to explore various aspects of attention deficit disorder and substance abuser subtypes. The purpose of the present study is to evaluate the effect of drug abuse on MMPI scale score profiles of alcoholics with or without attention deficit disorder symptoms. For the alcoholic group with ADDRT versus the alcoholic group with ADDRT and drug abuse there were no significant differences between the groups.

The perineal field in the external irradiation of cancer of the prostate: a modified Regato technique. First Annual del Regato Distinguished Lecture.

(1) 50 consecutive patients with cancer of the prostate, stages A2 through C2 received external irradiation. The whole pelvis was treated using 4-MV photons, and a prostate boost was given through the perineum using a cesium-137 teletherapy unit. (2) The treatment technique was easily duplicated daily and was well tolerated.

Modulation of salivary secretion by acid infusion in the distal esophagus in humans.

To examine the relationship between esophageal acid exposure and development of salivation and heartburn, 15 healthy subjects underwent perfusion of the distal esophagus with varying concentrations of hydrochloric acid, different-osmolality saline solutions, and deionized water. In five study subjects, hydrochloric acid was infused in the body of the stomach only. During the study, timed samples of whole and parotid saliva were collected and analyzed for flow rate and bicarbonate concentration.

Attention deficit disorder, alcoholism, and drug abuse: MMPI correlates.

Earlier research had demonstrated that alcoholics with attention deficit disorder residual type (ADDRT) differ from other alcoholics on the Minnesota Multiphasic Personality Inventory (MMPI). The purpose of this study was to explore the influence of drug abuse on the relationship of ADDRT and alcoholism as reflected on the MMPI. Groups of 48 male alcoholics, 28 ADDRT alcoholics, 25 ADDRT alcohol and drug abusers and 18 alcohol and drug abusers were all administered the MMPI.

Computerized interpretation of the Luria-Nebraska Neuropsychological Battery: a pilot study.

Programs for the computer analysis and interpretation of neuropsychological test data have been developed in recent years. In this paper, a new computer program, with initial validation data, is presented. Diagnostic hit rate for brain damage was 80% (52 of 65).

Dietary fiber supplementation: effect on exocrine pancreatic secretion in man.

The effect of a dietary fiber supplementation program (20 g/d) on exocrine pancreatic gland secretion was evaluated in six healthy male subjects who underwent quantitative assessment of pancreatic enzyme secretion both before and after 4 wk of dietary fiber supplementation. A duodenal perfusion technique was used to quantify the concentrations and output of pancreatic enzymes after ingestion of a standard test meal. Samples were aspirated from the ligament of Trietz and analyzed for pH, total protein, amylase, trypsin, and lipase activity.

Subtle/obvious MMPI scales identify attention deficit disorder alcoholics.

Earlier research has demonstrated that alcoholics with or without attention deficit disorders, residual type (ADDRT) can be differentiated by Minnesota Multiphasic Personality Inventory (MMPI) Clinical Scale Profiles. This study addressed the question of whether that differentiation was made by virtue of subtle or obvious aspects of the MMPI item pool. Groups of 30 of male alcoholics with or without ADDRT were individually matched on age and education variables.

Alcoholism and attention deficit disorder: MMPI correlates.

Previous research suggests that the alcoholic population can be meaningfully divided into subtypes, one of which is attention deficit disorder, residual type (ADDRT). The purpose of this study was to identify differences in personality profiles, as measured by the Minnesota Multiphasic Personality Inventory (MMPI), between ADDRT alcoholics and other alcoholics. Groups of 50 male ADDRT alcoholics and 50 male nonADDRT alcoholics were administered the MMPI.

External radiation therapy of stage I cancer of the endometrium: a need for reappraisal of this adjunctive modality.

One hundred and eighty-five patients with Stage I cancer of the endometrium were irradiated preoperatively. All were irradiated to the whole pelvis by external beam only using supermegavoltage apparati. The total mid-pelvis dose ranged from 4500 cGy/5 weeks to 5500 cGy/6 1/2 weeks.

Prostatic carcinoma: limited field irradiation.

This is a retrospective study of 251 patients with histologically proven adenocarcinoma treated primarily with limited field radiotherapy techniques, under the principle direction of authors JMV and JPG, between 1968 and 1981 in San Francisco, California. All patients are followed for a minimum of 3 years; mean follow-up is 7.3 years.

Gastric emptying in patients with insulin-requiring diabetes mellitus.

Gastric emptying of technetium labeled liquid and solid meals were studied in a group of long-standing, insulin-requiring male diabetics to evaluate the relationship of gastroparesis to symptoms, diabetic control, and diabetic complications. Control subjects and three groups of diabetics were studied: A) no neuropathy; B) peripheral neuropathy; and C) peripheral and autonomic neuropathy. Nine diabetics had gastrointestinal symptoms.

The influence of field size, treatment modality, commissure involvement and histology in the treatment of early vocal cord cancer with irradiation.

One hundred and thirty-seven patients with TNM staged T1 glottic cancer were treated from 1966 to 1980. The patient characteristics were no different from those noted in previous studies. Patients were treated either with 60Co teletherapy units or 4 MeV linear accelerators with different daily (180-225) and weekly (4 times vs.

Mediastinal Hodgkin's disease.

A group of five patients with Hodgkin's disease, nodular sclerosing in type, localized to the mediastinum (Stage IA) is reported. We believe that this presentation sometimes known as "granulomatous thymoma," warrants management in a manner somewhat different from that of the more common presentations of Hodgkin's disease. Nodular sclerosing Hodgkin's disease involving only the mediastinum affects a younger age group in whom the disease may be asymptomatic.

Carcinoma of the esophagus: an analysis of results and of treatment techniques.

Results of radiation therapy in 85 patients with squamous cell carcinoma of the esophagus are presented. Whereas the majority of patients with this tumor have been shown to die within the first year, occasional patients may survive longer (21.5 percent in this series); late radiation complications must therefore be maintained at a minimum.