Publications by authors named "V van Duinen"
Drug discovery for complex liver diseases faces alarming attrition rates. The lack of non-clinical models that recapitulate key aspects of liver (patho)-physiology is likely contributing to the inefficiency of developing effective treatments. Of particular notice is the common omission of an organized microvascular component despite its importance in maintaining liver function and its involvement in the development of several pathologies.
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- Puumala orthohantavirus (PUUV) can cause hemorrhagic fever with renal syndrome primarily through infection of endothelial cells, leading to increased vascular permeability.
- Traditional studies used static 2D cultures of endothelial cells, which do not accurately mimic the body's environment, prompting the need for better models.
- The new 3D vessels-on-chip model allows for a more realistic study of endothelial responses to PUUV, showing that infection increases monocyte adhesion instead of vascular permeability, and can potentially aid in researching treatments for similar viruses.
Article Synopsis
- Cancer increases the risk of venous thromboembolism, particularly in glioblastoma cases, highlighting the need for new models to study this issue at a molecular level.
- A novel cancer-on-a-chip model was created to analyze how glioblastoma cells affect blood coagulation by co-culturing glioblastoma spheroids with endothelial cells.
- Results showed that glioblastoma cells significantly heightened blood coagulation, and using anticoagulant drugs like rivaroxaban effectively reduced this coagulation in the model, suggesting its potential for discovering new anticoagulant therapies for glioblastoma and similar cancers.
Background And Aims: Endothelial cell (EC) dysfunction in response to circulating plasma factors is a known causal factor in many systemic diseases. However, no appropriate assay is available to investigate this causality . In liver cirrhosis, systemic inflammation is identified as central mechanism in progression from compensated to decompensated cirrhosis (DC), but the role of ECs therein is unknown.
View Article and Find Full Text PDFG protein-coupled receptors (GPCR) are involved in various physiological and pathophysiological processes. Functional autoantibodies targeting GPCRs have been associated with multiple disease manifestations in this context. Here we summarize and discuss the relevant findings and concepts presented in the biennial International Meeting on autoantibodies targeting GPCRs (the 4th Symposium), held in Lübeck, Germany, 15-16 September 2022.
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