Publications by authors named "V di Giacomo"
Dental inflammatory diseases remain a challenging clinical issue, whose causes and development are still not fully understood. During dental caries, bacteria penetrate the tooth pulp, causing pulpitis. To prevent pulp necrosis, it is crucial to promote tissue repair by recruiting immune cells, such as macrophages, able to secrete signal molecules for the pulp microenvironment and thus to recruit dental pulp stem cells (DPSCs) in the damaged site.
View Article and Find Full Text PDFObjective: Cold atmospheric plasma (CAP) is a novel approach for cancer treatment. It can be used to treat liquids-plasma-activated media (PAM)-which are then transferred to the target as an exogenous source of reactive oxygen and nitrogen species (RONS). The present study aimed at chemically characterizing different PAM and assessing their in vitro selectivity against head and neck cancer cells (HNC).
View Article and Find Full Text PDFArticle Synopsis
- - SARS-CoV-2 spike protein contributes to tissue inflammation by transforming M2 macrophages into a pro-inflammatory state, resembling M1 macrophages, which enhances lymphocyte activation and proliferation.
- - The spike protein activates the STAT1 signaling pathway in macrophages and endothelial cells, leading to increased inflammation and cell death, as indicated by Bax upregulation.
- - Using RGD mimetics like tirofiban can block the negative effects of the spike protein, decreasing inflammation and preventing cell death in both macrophages and endothelial cells.
Chronic wounds significantly impact the patients' quality of life, creating an urgent interdisciplinary clinical challenge. The development of novel agents capable of accelerating the healing process is essential. Caffeic acid phenethyl ester (CAPE) has demonstrated positive effects on skin regeneration.
View Article and Find Full Text PDFBackground: Nanoplastics, an emerging form of pollution, are easily consumed by organisms and pose a significant threat to biological functions due to their size, expansive surface area, and potent ability to penetrate biological systems. Recent findings indicate an increasing presence of airborne nanoplastics in atmospheric samples, such as polystyrene (PS), raising concerns about potential risks to the human respiratory system.
Methods: This study investigates the impact of 800 nm diameter-PS nanoparticles (PS-NPs) on A549, a human lung adenocarcinoma cell line, examining cell viability, redox balance, senescence, apoptosis, and internalization.