Publications by authors named "V Zidlik"

The recent introduction of the WHO cytology classification of pancreatobiliary tumours aimed to improve the diagnosis and management of these tumours. The present paper briefly describes the methods of diagnosis. Emphasis is then put on a detailed comparison of the previous Papanicolaou classification and the new WHO classification and description of the changes brought about by the introduction of the WHO classification.

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Article Synopsis
  • A 74-year-old kidney transplant patient developed iatrogenic Kaposi's sarcoma (KS) affecting his lower eyelids and later confirmed in the left forearm and suspected in the lungs.
  • The tumor on the eyelids was surgically removed with clean margins, while the forearm lesion was also excised. The patient received radiotherapy for lung issues and adjustments to his immunosuppressive therapy.
  • The case underscores the need for early detection of KS, thorough histological diagnosis, surgical removal, and teamwork among medical professionals for effective treatment outcomes.
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Extramedullary multiple myeloma (EMM) is an aggressive form of multiple myeloma (MM). This study represents the most comprehensive next-generation sequencing analysis of EMM tumors (N = 14) to date, uncovering key molecular features and describing the tumor microenvironment. We observed the co-occurrence of 1q21 gain/amplification and MAPK pathway mutations in 79% of EMM samples, suggesting that these are crucial mutational events in EMM development.

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Sarcoidosis is a disease characterised primarily by lung tissue involvement. Extrapulmonary involvement, particularly in the genitourinary tract, is extremely rare, particularly when it comes to primary disease detection in this location. The gold standard in establishing a definitive diagnosis of sarcoidosis is a combination of the clinical picture, the results of imaging methods, and histopathological examination from the biopsy taken (thus ruling out other causes of granulomatous inflammation).

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  • Leiomyosarcoma with adipocytic differentiation, or lipoleiomyosarcoma, is a rare type of tumor found in the female reproductive system, and this study analyzed its characteristics in a series of cases to better understand this condition.
  • Six tumors from six patients were studied, showing different kinds of lipoleiomyosarcoma, with patient ages between 41 and 64, and primary tumors located mainly in the uterine corpus.
  • The study found similarities in immunohistochemical markers and genetic alterations between lipoleiomyosarcomas and non-adipocytic gynecologic leiomyosarcomas, indicating they may share underlying characteristics despite their different appearances.
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