Impact of Vitamin D3 on Carbonyl-Oxidative Stress and Matrix Metalloproteinases after Acute Intracerebral Hemorrhage in Rats with Type 2 Diabetes Mellitus.

Introduction: Diabetes mellitus is associated with the development of carbonyl-oxidative stress (COS) and an increased risk of a cerebral hemorrhage. Vitamin D3 is considered an additional drug to have an impact on COS and proteolysis in the extracellular matrix.

Objective: The study aimed to evaluate the impact of D3 on the COS-markers and matrix metalloproteinases MMP2/MMP9 activity after acute intracerebral hemorrhage (ICH) in rats with experimental type 2 diabetes mellitus (Т2DM) compared to metformin (Met).

ANTIBACTERIAL THERAPY FOR PURULENT-SEPTIC COMPLICATIONS IN PATIENTS WITH COMBAT RELATED PENETRATING CRANIOCEREBRAL GUNSHOT WOUNDS.

Aim - to evaluate pathogens and their susceptibility to antibiotic therapy (ABT) in combat-related penetrating craniocerebral gunshot wound (PCGW) patients and develop recommendations for treatment of post-traumatic meningoencephalitis. We conducted a prospective analysis of examination and treatment results of 121 patients who were admitted to the Public Institution, Mechnikov Dnipropetrovsk Regional Clinical Hospital, Dnipro, Ukraine, from 25 May 2014, to 31 December 2017, and were successively enrolled in the study. Intracranial purulent-septic complications were diagnosed in 14 (11.

CARDIOVASCULAR SYSTEM AND MUSCULOSKELETAL CHANGES OF THE SPORTSMEN WITH POLYMORPHISMS OF COL1A1 GENE.

The purpose of the study of the study is an identification of the extension and impact of polymorphism of COL1A1 gene on cardiovascular system and musculoskeletal state of athletes. 85 people in the ages from 9 to 32 (the average age was 23.2±4.