Publications by authors named "V Zambelli"
Introduction: The advocacy Women Against Lung Cancer in Europe (WALCE) promoted the European Program for the Routine Testing of Patients With Advanced Lung Cancer (EPROPA) and provided a free-of-charge molecular profiling platform for NSCLC sample characterization with the aim of increasing the detection of targetable drivers and improving patients' access to clinical trials in Europe.
Methods: From January 2021 to December 2023, 20 centers located at five different European countries (Greece, Slovenia, Romania, Albania, and Italy) joined EPROPA, with 555 patients with advanced NSCLC registered to the program. Anonymized patients' clinical-pathological data were shared through the EPROPA web platform and tissue samples were collected at the Molecular Pathology Unit of the Reference Center (University of Turin) for molecular analyses.
Aldehyde dehydrogenase-2 deficiency (ALDH2∗2) found in 36 % of Han Chinese, affects approximately 8 % of the world population. ALDH2 is a mitochondrial key enzyme in detoxifying reactive aldehydes to less reactive forms. Studies demonstrate a potential link between ALDH2∗2 mutation and neurodegenerative diseases.
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- CRALE (Cardiopulmonary resuscitation-associated lung edema) is a condition observed in patients who undergo cardiac arrest and CPR, influencing both respiratory and cardiovascular systems.
- An experimental model of cardiac arrest was used to study CRALE, with manual and mechanical chest compressions compared, showing significant respiratory complications due to decreased lung compliance and poor oxygen delivery.
- Results indicated that after 25 minutes of CPR, animals exhibited signs of CRALE such as increased lung weight and reduced aeration, suggesting a correlation between CPR mechanics and lung edema severity.
Article Synopsis
- The study focused on creating models to predict the need for invasive mechanical ventilation (IMV) in ICU patients with COVID-19, comparing their efficacy to the existing ROX index.
- Conducted in three hospitals in Rio de Janeiro, Brazil, the study analyzed data from 656 ICU patients, ultimately including 346 after applying various exclusion criteria.
- Key predictors for IMV identified were arterial hypertension, diabetes, obesity, and the SOFA score, with the SOFA score showing the strongest association; the ROX index was also notably lower in patients needing IMV.
Correction: Bufalo et al. Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds. 2022, , 247.
Cells
June 2024
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