Exploring Ion Channel Magnetic Pharmacology: Are Magnetic Cues a Viable Alternative to Ion Channel Drugs?

We explore the potential of using magnetic cues as a novel approach to modulating ion channel expression, which could provide an alternative to traditional pharmacological interventions. Ion channels are crucial targets for pharmacological therapies, and ongoing research in this field continues to introduce new methods for treating various diseases. However, the efficacy of ion channel drugs is often compromised by issues such as target selectivity, leading to side effects, toxicity, and complex drug interactions.

Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields.

Calcium signaling plays a crucial role in various physiological processes, including muscle contraction, cell division, and neurotransmitter release. Dysregulation of calcium levels and signaling has been linked to a range of pathological conditions such as neurodegenerative disorders, cardiovascular disease, and cancer. Here, we propose a theoretical model that predicts the modulation of calcium ion channel activity and calcium signaling in the endothelium through the application of either a time-varying or static gradient magnetic field (MF).

Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis.

F-actin (filamentous actin) has been shown to be sensitive to mechanical stimuli and play critical roles in cell attachment, migration, and cancer metastasis, but there are very limited ways to perturb F-actin dynamics with low cell toxicity. Magnetic field is a noninvasive and reversible physical tool that can easily penetrate cells and human bodies. Here, we show that 0.

Interaction of magnetic fields with biogenic magnetic nanoparticles on cell membranes: Physiological consequences for organisms in health and disease.

The interaction mechanisms between magnetic fields (MFs) and living systems, which remained hidden for more than a hundred years, continue to attract the attention of researchers from various disciplines: physics, biology, medicine, and life sciences. Revealing these mechanisms at the cellular level would allow to understand complex cell systems and could help to explain and predict cell responses to MFs, intervene in organisms' reactions to MFs of different strengths, directions, and spatial distributions. We suggest several new physical mechanisms of the MF impacts on endothelial and cancer cells by the MF interaction with chains of biogenic and non-biogenic magnetic nanoparticles on cell membranes.