Photochemical Metal-Free synthesis and biological Assessment of isocryptolepine analogues targeting estrogen receptor Alpha in breast cancer cells.

The aim of this study was to develop a new series of isocryptolepines and evaluate their antiproliferative and antiestrogenic activities on cancer cells. A series of isocryptolepine derivatives were synthesized using developed one-pot photochemical, metal-free protocol, employing readily available 2-arylindoles as starting compounds. The resulting isocryptolepines demonstrated (sub)micromolar inhibitory activity against selected breast cancer cell lines.

Photoreactions of Semi-Stiff-Diarylethenes Based on the Cyclohexenol Motif.

Nonsymmetric diarylethenes with an additional "stiff" cyclohexenol ring undergo various types of tandem transformations launched by light-induced 6π-photocyclization. Among these, there are two novel reactions (formal [1,3]-H migration and complete aromatization to an anthracene derivative) as well as photorearrangement and formal methane elimination. This diverse reactivity demonstrates the great potential of --diarylethenes in synthetic photochemistry.

Switching the regioselectivity of acid-catalyzed reactions of arylnaphtho[2,1-]furans a [1,2]-aryl shift.

The [1,2]-aryl shift reaction was used to synthesize naphtho[2,1-]furans as promising fluorescent scaffolds for organic electronics. The target compounds are furan analogues of phenanthrene formally accessed by isosteric replacement of the CHCH moiety with an oxygen atom. The straightforward and robust approach involving a [1,2]-aryl shift as a key step provides easy access to a wide range of naphtho[2,1-]furans with the possibility of late-stage functionalization.

Riboflavin Crystals with Extremely High Water Solubility.

New insights into the unique biochemical properties of riboflavin (Rf), also known as vitamin B2, are leading to the development of its use not only as a vitamin supplement but also as a potential anti-inflammatory, immunomodulatory, antioxidant, anticancer, and antiviral agent, where it may play a role as an inhibitor of viral proteinases. At the same time, the comparison of the pharmacoactivity of Rf with its known metabolites, namely, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), is very complicated due to its poor water solubility: 0.1-0.