Current Role of Modern Chromatography with Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy in the Investigation of Biomarkers of Endometriosis.

Endometriosis has a wide range of clinical manifestations, and the disease course is unpredictable, making the diagnosis a challenging task. Despite significant advances in the pathophysiology of endometriosis and various proposed theories, the exact etiology is not fully understood and is still unknown. The most commonly used biomarker of endometriosis is CA-125, however, it is nonspecific and is applied for cancers diagnosis.

Strengthening Mechanisms in CoCrFeNiX (Al, Nb, Ta) High Entropy Alloys Fabricated by Powder Plasma Arc Additive Manufacturing.

In high entropy alloys (HEAs), the addition of large-size atoms results in lattice distortion and further leads to solid solution strengthening or precipitation strengthening. However, the relationship between atomic radius, solid solution strengthening and precipitation strengthening has not been discerned yet. In this work, CoCrFeNiX (X = Al, Nb, Ta, with an equi-atomic radius) HEAs were prepared by powder plasma arc additive manufacturing (PPA-AM) and evaluated for their mechanical properties.

Prostate cancer screening using chemometric processing of GC-MS profiles obtained in the headspace above urine samples.

The development of screening methods for various types of cancer is of utmost importance as the early diagnostics of these diseases significantly increases the chances for patient's successful medical treatment and recovery. In this study we have developed the procedure for chromatographic profiling of urine samples based on solid-phase microextraction and GC-MS. 50 urine samples (20 from the patients with biopsy conformed prostate cancer and 30 from control group) were studied in the optimized experimental conditions.

Accuracy and efficiency of electronic energies from systematic molecular fragmentation.

A systematic method for approximating the ab initio electronic energy of molecules from the energies of molecular fragments is tested on a large sample of typical organic molecular structures. The detailed methods, including some additional refinements for molecular rings and long range interactions, are described. The accuracy and computational efficiency of the systematic hierarchy of methods are reported.

[Main principles of antibiotic prophylaxis and antibacterial therapy in abdominal surgery].

The principles of antibioticoprophylaxis and antibacterial therapy in abdominal surgery were expounded. There are adduced the most frequently revealed pathogenic microorganisms, inducing intraabdominal infection, the ways of lowering of the antibacterial therapy expenses, new approaches to application of immunocorrection and directed transport of antibiotics in surgery as well as empirical and etiotropic treatment, basing on the taking account of the spread and antibioticosensitivity of pathogenic microorganisms of nosocomial infections. There was shown, that concentration of interleucin-1beta and tumor necrosis factor-alpha in the blood serum is connected with the severity of patient state.