Searching for New Biomarkers to Assess COVID-19 Patients: A Pilot Study.

During the initial diagnosis of urgent medical conditions, which include acute infectious diseases, it is important to assess the severity of the patient's clinical state as quickly as possible. Unlike individual biochemical or physiological indicators, derived indices make it possible to better characterize a complex syndrome as a set of symptoms, and therefore quickly take a set of adequate measures. Recently, we reported on novel diagnostic indices containing butyrylcholinesterase (BChE) activity, which is decreased in COVID-19 patients.

Antiviral Activity of Nitrosonium Cations against SARS-CoV-2 on a Syrian Hamster Model.

The antiviral action of binuclear dinitrosyl iron complexes with glutathione along with diethyldithiocarbamate against the SARS-CoV-2 virus has been demonstrated on a Syrian hamster model after aerosol exposure of SARS-CoV-2-infected animals to the solutions of said compounds. EPR assays in analogous experiments on intact hamsters have demonstrated that the iron complexes and diethyldithiocarbamate are predominantly localized in lung tissues. These results have been compared with similar measurements on intact mice, which have shown the equal localization of these agents in both the lungs and liver.

[Autoantibodies to thyroid antigens levels in the population of the Russian Arctic at different levels of blood dopamine.].

Neuroimmunoendocrine regulation of the thyroid gland involves the use of autoantibodies as regulatory molecules to stimulate or reduce the activity of the tissues of the organ itself. A huge number of regulatory signal molecules and factors, acting directly or indirectly, often plays a much more significant role, both in ensuring normal activity and in pathological processes. In this regard, it was interesting for us to determine the possible effect of dopamine at its various concentrations in the blood on the levels of thyroglobulin and antibodies to thyroid antigens.

[Levels of sex hormones, sex hormone binding globulin, antisperm antibodies and dopamine in postmanopausal women of nomadic and settled aboriginal and local caucasoid populations of the arctic territories.].

Positive changes in the society led to an improvement in quality and lifetime; as a result the menopause in women lengthens much longer, in light of this the relevance of studying hormonal changes increases, especially among the representatives of different groups living in the Arctic territories. The study was carried out on 138 women who included nomadic and settled aboriginal and local Caucasoid postmenopausal populations, permanently residing in the Arctic territories of Russia. The greatest difference in the studied blood indicators was shown between the local Caucasoid and aboriginal population.

[Pituitary-gonadal and pituitary-thyroid axis hormone serum levels in postmenopausal women of the European North of the Russian Federation, depending on the age.].

Using the methods of radioimmunoassay and enzyme immunoassay there were studied the levels of hormones of the pituitary-thyroid and pituitary-gonadal systems in the postmenopausal women of the European North of the Russian Federation in the second period of mature age, elderly and senile ages. The lower concentrations of total and free fractions of triiodothyronine and total thyroxin, testosterone, dehydroepiandrosterone sulfate, and estradiol were noted in the blood of investigated women in the senile age. Excess levels of thyroid-stimulating hormone were shown in 12,1% of people in the II period of mature age and 17,4% of people in the elderly age.