[CURRENT STATE OF ADJUVANT TREATMENT FOR GASTRIC CANCER AFTER RADICAL SURGERY WITH EXTENDED LYMPH NODE DISSECTION].

There are presented results of recently published large multicenter randomized trials on the effectiveness of different adjuvant therapy regimens after gastrectomy D2 in patients with gastric cancer. It is shown that adjuvant chemotherapy as monotherapy by drug S-1 and polychemotherapy by XELOX improves long-term outcomes of patients with stages 2-3. At the same time the intensification of therapy--additional administration of paclitaxel, the combination FOLFIRI scheme with docetaxel and cisplatin--have not led to a significant increase in survival rate.

[The influence of lymphadenectomy on the results of the gastric cancer treatment].

Results of randomized studies and meta-analyses of the long-term results of surgical treatment of the gastric cancer with lymphadenectomy were compared. The D2 lymphadenectomy permits low indices of postoperative morbidity and mortality. The further lymphadenectomy volume increase does not lead to the significant improvement of the long term treatment results.

[Multiple neoplasms in gastric cancer patients: patterns of development, results of treatment].

Patterns of polyneoplasia development were analyzed in radically operated gastric cancer patients. The second tumors were revealed in 99 of 1255 patients (7,9%) as soon as patients with early gastric cancer manifested primary-multiple malignant tumors almost two times more (15,4%). Among second tumors there were predominantly tumors of the colon, urogenital system, head and neck and also lymphoproliferative diseases.

[D2 lymphadenectomy for surgical and combined treatment of the gastric cancer].

Immediate results of 100 D2 lymphadenectomies, performed for gastric cancer, were analyzed. The combined treatment included preoperative radiotherapy (n=39), combinations of pre- and postoperative radiotherapy (n=18) and adjuvant chemotherapy (n=18). The majority of patients had tumors of the lower third of the stomach, histologically low- and non-differentiated adenocarcinomas.

[Effect of morphologic features on recurrence and metastasis in stomach cancer].

Data on examination of 192 patients radically operated for stomach cancer at the Center's Clinic were analyzed vis-a-vis postoperative recurrences. Marked dependence of metastatic spread features and pathway on histological pattern of tumor was established. This can be used in working out therapeutic strategies.