Perfluoroaromatic Bisselanes: From Molecular Design to Supramolecular Architecture Through Tandem σ/π-hole Interactions.

The molecular design of a series of perfluoroarylbisselanes (30-68 %) o-, m- and p-(ArSe)CF and (ArSe)CF (Ar=CF and p-CFCF) were achieved through the reaction of ArSeCu with diiodoperfluoroarenes bearing phenyl and biphenyl rings. Analysis of the X-ray diffraction (XRD) data for the resulting perfluoroaromatic bisselanes 5-12 demonstrated their significant potential for constructing supramolecular architectures through tandem noncovalent interactions, including chalcogen bonding (ChB) and π-π interactions. 1,2-Bis(pentafluorophenylseleno)tetrafluorobenzene 5 was cocrystallized with dibenzyl ether, yielding the adduct 5⋅BnO, which exhibited a triad structural motif.

Rapid Raman spectroscopy-based test for antimicrobial resistance.

Antimicrobial resistance (AMR) is one of the top global health threats. In 2019, AMR was associated with 4.95 million deaths, of which 1.

Different Stacking Types in a Single Hybrid Cocrystal System: π···π- and π-Hole-Based Organic-Inorganic Planar Assemblies.

The planar bis-chelated complex [Pd(NO)] (; NO = 4-MeCHNNC(O)NMe) exhibits two distinct stacking modes with electron-deficient aromatics: π···π stacking with hexafluorobenzene (CF) versus charge-transfer π-hole interactions with 1,2,4,5-tetracyanobenzene (TCB). Cocrystallization of the complex with CF or TCB yields cocrystals ·3(CF) and ·2TCB, respectively, which display different colors and stacking patterns despite similar structural motifs. Comprehensive analysis using X-ray diffraction, combined with quantum theory of atoms-in-molecules (QTAIM), an independent gradient model based on Hirshfeld partition (IGMH), extended transition state natural orbital for chemical valence theory with charge displacement function (ETS-NOCV/CDF), many-body interaction analysis, and symmetry-adapted perturbation theory (SAPT), reveals fundamentally different interaction mechanisms.

[Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay].

Currently, empirical therapy regimens are often used in the treatment of infectious diseases that are not based on data on pathogen resistance. One of the main reasons for the unjustified prescription of antibacterial drugs is the lack of rapid and at the same time universal methods of determining the antibiotic resistance of the pathogen. The most widely used culture techniques, such as the microdilution method, require a long time to generate the necessary number of bacterial cells.

The freeze-thaw cycle effect on blood serum autofluorescence, Raman spectroscopy and SERS: implications for sample classification and disease diagnostics.

The issue of variability introduced into blood plasma and serum analysis by preanalytical procedures is the major obstacle to obtaining accurate and reproducible results. While the question of how to overcome this issue has been discussed in biochemical detection of analytes and omics technologies, its relevance to the field of optical spectroscopy remains mostly unexplored. In this work, we evaluated the freeze-thaw cycle (FTC)-induced alternations in blood serum optical properties by means of autofluorescence and Raman spectroscopy, including surface-enhanced Raman spectroscopy (SERS).