Publications by authors named "V Wykes"
Aims: Tissue V12Gy (total brain volume receiving 12Gy including target) can predict for late toxicity in single target benign disease treated with stereotactic radiosurgery (SRS). The value of this metric remains uncertain for multiple brain metastases. This retrospective cohort study reports the outcomes and evaluates the predictors of toxicity in patients with four or more brain metastases treated with single-fraction SRS.
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- Patients with brain tumors want to help doctors understand their illness better by participating in tests that involve taking samples of their tumor tissue.
- To improve treatments, everyone including patients, researchers, and regulatory agencies need to work together and use consistent methods when taking these samples.
- Even though new tests using blood samples show some promise, they can't replace the need for the usual tissue tests just yet, and it's important to clearly explain the risks and benefits of these procedures to patients.
Article Synopsis
- The study focuses on the T2-FLAIR mismatch sign, which indicates a specific type of astrocytoma with IDH mutations, and how this sign changes as the tumor progresses.
- A total of 128 IDH-mutant gliomas were analyzed using advanced MRI techniques to observe the evolution of the T2-FLAIR mismatch and the tumors' internal variations over time.
- The research shows that smaller tumors start as uniform T2 lesions but develop a T2-FLAIR mismatch as they grow, while larger tumors demonstrate increased heterogeneity, suggesting a progression to higher grade tumors.
Article Synopsis
- A diagnostic delay in identifying primary central nervous system lymphoma (PCNSL) often arises from recognizing lesions incorrectly and premature steroid treatment, complicating biopsy results.
- Multiparametric MRI, which includes advanced imaging techniques, is emphasized as crucial for reducing diagnostic uncertainties in PCNSL cases.
- In a study of 10 patients, most exhibited consistent MRI parameters indicative of PCNSL, suggesting this imaging approach could streamline diagnosis and hasten treatment initiation.
Aim: To investigate whether T2-weighted imaging-fluid-attenuated inversion recovery (T2/FLAIR) mismatch, T2∗ dynamic susceptibility contrast (DSC) perfusion, and magnetic resonance spectroscopy (MRS) correlated with the histological diagnosis and grading of IDH (isocitrate dehydrogenase)-mutant, 1p/19q non-co-deleted/ATRX (alpha-thalassemia mental retardation X-linked)-mutant astrocytoma.
Materials: Imaging of 101 IDH-mutant diffuse glioma cases of histological grades 2-3 (2019-2021) were analysed retrospectively by two neuroradiologists blinded to the molecular diagnosis. T2/FLAIR mismatch sign is used for radio-phenotyping, and pre-biopsy multiparametric MRI images were assessed for grading purposes.