Publications by authors named "V Wongchai"
Purpose: Ibrutinib is a first-in-class inhibitor of Bruton tyrosine kinase. We previously reported the safety and short-term antitumor activity of ibrutinib in 20 patients with relapsed or refractory (r/r) primary central nervous system (CNS) lymphoma (PCNSL) or secondary CNS lymphoma (SCNSL).
Patients And Methods: We enrolled 26 additional patients with r/r PCNSL/SCNSL into the dose-expansion cohort of the trial into a combined cohort of 46 patients (31 with PCNSL and 15 with SCNSL).
Article Synopsis
- * A study tested the feasibility of administering HD-MTX in an outpatient setting with the aid of low-dose glucarpidase to help clear the drug more quickly.
- * Results showed that all treatments were effective and safe, with no hospitalizations needed, suggesting that outpatient HD-MTX with glucarpidase could change how CNS lymphoma is treated.
Objective: This study investigates the prevalence of COVID-19-related discrimination and the extent to which COVID-19-related discrimination is associated with mental health symptoms among Asians and Asian American (A/AA) young adults during the first three months of the COVID-19 pandemic.
Methods: We used data from the COVID-19 Adult Resilience Experiences Study (CARES), a cross-sectional online survey conducted in the U.S.
Article Synopsis
- A new phorbol ester, named DHPB, was isolated from Jatropha curcas seed oil and is structurally characterized as an intramolecular 13,16-diester of 12-deoxy-16-hydroxyphorbol.
- DHPB exhibited biological activity by inducing enzymes and activating receptors, but its effects were slightly weaker compared to a more common phorbol ester, TPA.
- In a mouse skin study, DHPB showed weak tumor-promoting potential, resulting in a 46.7% tumor incidence when applied after a carcinogen, indicating it may have some carcinogenic effects, albeit less than TPA.
The seed oil of Jatropha curcas L. was shown to contain skin tumor promoters in a two-stage mouse carcinogenesis experiment. By using the irritant test on mouse ear to monitor activity, the "irritant fraction" was partially purified from the methanol extract of the seed oil by column chromatographies on Florisil and Sephadex LH-20.
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