Combination of selective androgen and estrogen receptor modulators in orchiectomized rats.

Purpose: Selective androgen and estrogen receptor modulators, ostarine (OST) and raloxifen (RAL), reportedly improve muscle tissue and offer therapeutic approaches to muscle maintenance in the elderly. The present study evaluated the effects of OST and RAL and their combination on musculoskeletal tissue in orchiectomized rats.

Methods: Eight-month-old Sprague Dawley rats were analyzed.