Publications by authors named "V Wolf"
Article Synopsis
- Ceramides are crucial lipids that help form sphingolipids and serve as signaling molecules, synthesized through a reaction catalyzed by ceramide synthase (CerS) enzymes.
- Using cryo-electron microscopy, researchers determined the structure of the yeast CerS complex in both its active form and when inhibited by fumonisin B1, revealing a dimer composition of Lip1 and the catalytic subunits Lag1 and Lac1.
- The study identified a hydrophobic crevice in the catalytic subunits that connects different cellular sites and showed an intermediate state of ceramide synthesis, highlighting the competitive binding of fumonisin B1 in the acyl-CoA-binding region.
Pancreatic ductal adenocarcinoma (PDAC) remains a particularly aggressive disease with few effective treatments. The PDAC tumor immune microenvironment (TIME) is known to be immune suppressive. Oncolytic viruses can increase tumor immunogenicity via immunogenic cell death (ICD).
View Article and Find Full Text PDFObjective: By providing a structured assessment of specific risk factors, risk assessment tools allow statements to be made about the likelihood of future recidivism in people who have committed a crime. These tools were originally developed for and primarily tested in men and are mainly based on the usual criminological background of men. Despite significant progress in the last decade, there is still a lack of empirical research on female offenders, especially female forensic psychiatric inpatients.
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- The cacao swollen shoot disease (CSSD), caused by various badnavirus species, poses significant challenges for cacao production in West Africa, particularly in Ghana and Côte d'Ivoire.
- The study aimed to assess the effectiveness and diversity of CSSD species detection, employing methods like field surveillance and PCR assays, and found a detection efficiency ranging from 0.15% to 66.91% across different primer sets used.
- Among the identified species, the cacao swollen shoot Togo B virus (CSSTBV) was the most common, while the cacao swollen shoot CE virus (CSSCEV) was mainly found in border areas; these findings enhance our understanding of CSSD species distribution and assist in improving diagnostic strategies for
Given the crucial role of the main protease (M) in the replication cycle of SARS-CoV-2, this viral cysteine protease constitutes a high-profile drug target. We investigated peptidomimetic azapeptide nitriles as auspicious, irreversibly acting inhibitors of M. Our systematic approach combined an M active-site scanning by combinatorially assembled azanitriles with structure-based design.
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