Publications by authors named "V Witte"
Article Synopsis
- - White matter hyperintensities indicate damage in the brain's white matter, which can lead to brain shrinkage and is linked to dementia; a study of over 51,000 people found that larger volumes of these hyperintensities correspond to thinner brain cortex.
- - Researchers identified 20 significant genetic loci related to white matter hyperintensities that affect genes involved in brain cell types known to support vascular health and neuronal function; some of these genes play roles in processes like axonal structure and transport within the brain.
- - The genetic traits tied to white matter issues were linked to cardiovascular health, neurodegeneration markers, and poorer cognitive performance, with a polygenic risk score effectively predicting dementia risk in a separate large
Article Synopsis
- Alzheimer's disease (AD) is marked by cognitive decline and specific brain atrophy, particularly affecting the medial temporal lobes, yet hypothalamic atrophy in AD has been less studied, especially in its early stages.
- * Researchers analyzed hypothalamic volume using advanced MRI techniques on a sample of 175 participants including cognitively normal individuals, those with mild cognitive impairment, and AD patients, aiming to explore structural changes associated with the disease.
- * Results indicated that hypothalamic atrophy occurs in both early and late stages of AD, showing relationships with key brain regions involved in autonomic function, though group differences in hypothalamic structure were not significant.
Background: We recently reported that Mediterranean (MED) and green-MED diets significantly attenuated age-related brain atrophy by ∼50% within 18 mo.
Objective: The objective of this study was to explore the contribution of specific diet-induced parameters to brain-volume deviation from chronologic age.
Methods: A post hoc analysis of the 18-mo DIRECT PLUS trial, where participants were randomly assigned to the following groups: 1) healthy dietary guidelines, 2) MED diet, or 3) green-MED diet, high in polyphenols, and low in red meat.
Objective: The bejective was to determine health literacy (HL) and care aspects of those affected by Long-COVID.
Method: 407 patients with Long-COVID and long-term neuropsychiatric symptoms were interviewed in the LIFE study center. In addition to descriptive analyses, regression models were calculated to examine the relationships between health literacy (HLS-EU-Q16) and various aspects of care (RehaQ-N1).
Background: Obesity is a multifactorial condition. Genetic variants, such as the fat mass and obesity related gene (FTO) polymorphism, may increase the vulnerability of developing obesity by disrupting dopamine signaling within the reward network. Yet, the association of obesity, genetic risk of obesity, and structural connectivity of the reward network in adolescents and young adults remains unexplored.
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