Publications by authors named "V Waller"
Purpose: Ionizing radiation (IR) enhances the migratory capacity of cancer cells. Here we investigate in non-small-cell-lung-cancer (NSCLC) cells a novel link between IR-enhanced ADAM17 activity and the non-canonical pathway of EphA2 in the cellular stress response to irradiation.
Methods: Cancer cell migration in dependence of IR, EphA2, and paracrine signaling mediated by ADAM17 was determined using transwell migration assays.
Article Synopsis
- FLT3 is a protein that is often overexpressed or mutated in acute myeloid leukemia (AML), making treatment challenging, even with existing therapies like receptor tyrosine kinase inhibitors (TKIs).
- Researchers developed a new antibody-drug conjugate (ADC) called 20D9-ADC, which effectively targets FLT3 and shows significant cytotoxic effects against various AML cells in lab tests and promising results in animal models.
- The combination of 20D9-ADC with the TKI midostaurin demonstrated strong effectiveness, suggesting a powerful new treatment strategy for FLT3-ITD-positive AML with reduced side effects.
Objective: Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined treatment concepts targeting HRR provide a rational for potential pharmaceutical exploitation. The HSP90 inhibitor ganetespib (STA-9090) downregulates a multitude of HRR-associated proteins and sensitizes for certain chemotherapeutics.
View Article and Find Full Text PDFUnlabelled: The cellular response to ionizing radiation (IR) depends on tumor cell and microenvironmental factors. Here, we investigated the role of IR-induced ADAM17 matrix metalloproteinase activity for the intercellular communication between tumor cells and the tumor vasculature in non-small cell lung cancer (NSCLC) tumor models. Factors shed by ADAM17 from NSCLC tumor cells (A549, H358) and relevant for endothelial cell migration were investigated using transwell migration assays, ELISA, and flow cytometry.
View Article and Find Full Text PDFBackground: Accumulating evidence suggests that the COVID-19 pandemic has negatively impacted the mental health of individuals. However, the susceptibility of individuals to be impacted by the pandemic is variable, suggesting potential influences of specific factors related to participants' demographics, attitudes, and practices.
Objective: We aimed to identify the factors associated with psychological symptoms related to the effects of the first wave of the pandemic in a multicountry cohort of internet users.