Publications by authors named "V W Van Hinsbergh"
Article Synopsis
- Endothelial barrier disruption plays a crucial role in organ dysfunction during inflammatory conditions like sepsis, and the kinase Arg/Abl2 has been identified as a key mediator of this disruption.
- Depleting Arg in endothelial cells activates RhoA and Rac1, enhancing cell adhesion and reducing cell retraction and gap formation.
- Genetic deletion of Arg in vivo reduces vascular leaks in the skin and lungs, highlighting its importance as a potential therapeutic target for conditions associated with vascular leakage.
Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk leading to impairment of cardiomyocyte function is not known. The sodium-glucose co-transporter 2 inhibitor, empagliflozin, reduced cardiovascular events in diabetic patients with or without CKD, suggesting its potential as a new treatment for heart failure with preserved ejection fraction.
View Article and Find Full Text PDFEndothelial barrier dysfunction leads to edema and vascular leak, causing high morbidity and mortality. Previously, Abl kinase inhibition has been shown to protect against vascular leak. Using the distinct inhibitory profiles of clinically available Abl kinase inhibitors, we aimed to provide a mechanistic basis for novel treatment strategies against vascular leakage syndromes.
View Article and Find Full Text PDFArticle Synopsis
- * In a study using mice, researchers examined how the presence or absence of PVAT affects muscle perfusion and glucose uptake during insulin stimulation, finding that PVAT is essential for proper IMVR.
- * The removal of PVAT not only disrupted the blood flow to muscles but also altered important protein clusters involved in metabolism, indicating a significant role of PVAT in managing vascular health and metabolic processes relevant to conditions like obesity and diabetes.