Publications by authors named "V Vinothkumar"
Nanobiosensors based on on-site detection approaches for rapid pesticide sensing in the agricultural arena: A systematic review of the current status and perspectives.
Biotechnol Bioeng
September 2024
The extensive use of chemical pesticides has significantly boosted agricultural food crop yields. Nevertheless, their excessive and unregulated application has resulted in food contamination and pollution in environmental, aquatic, and agricultural ecosystems. Consequently, the on-site monitoring of pesticide residues in agricultural practices is paramount to safeguard global food and conservational safety.
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- - ERCC1/XPF is an important protein for repairing DNA damage caused by certain chemotherapy drugs, and researchers found that lung cancer cells lacking ERCC1 and p53 can resist platinum-based chemotherapy.
- - Inhibiting ATR, a protein that helps maintain DNA replication, restored sensitivity to platinum in these resistant cells by affecting replication fork protection and cell cycle checkpoints.
- - Combining ATR inhibitors with platinum treatment not only increased DNA damage but also showed promise for enhancing immunotherapy effectiveness, making it a potential strategy to treat ERCC1-deficient lung cancers.
A new electrochemical sensor has been constructed based on the preparation of gold nanoparticle embedded on reduced graphene oxide and polypyrrole nanotube (AuNP@rGO/PPyNT) composite through a nanosecond laser-induced heating technique. The as-prepared composite is used for individual as well as the simultaneous electrochemical determination of chemotherapy drug (furazolidone, FU) and anticancer drug (flutamide, FLT). The composite was analyzed by X-ray Diffraction, scanning electron microscopy/energy-dispersive X-ray analysis, transmission electron microscopy, Raman spectrometry, and X-ray photoelectron spectroscopy analysis, thus confirming the successful synthesis of this composite and its physical features.
View Article and Find Full Text PDFObjectives: To evaluate the anti-inflammatory and antiproliferative effect of syringic acid (SRA) on oral squamous cell carcinoma (OSCC) SCC131 cells via suppression of NF-κB-induced PI3K/Akt signalling pathway.
Methods: The present study assesses the anticancer effects of SRA alongside human oral cancer (HOC) SCC131 cells through the fabrication of reactive oxygen species (ROS) and activated apoptosis. DAPI and Rh-123 staining were used to assess the apoptotic nuclear characteristic, mitochondrial membrane potential, cell adhesion and migration by fluorescence microscope with SRA treatment.