Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression.

H2A.Z is a H2A-type histone variant essential for many aspects of cell biology, ranging from gene expression to genome stability. From deuterostomes, H2A.

How rare are power-law networks really?

The putative scale-free nature of real-world networks has generated a lot of interest in the past 20 years: if networks from many different fields share a common structure, then perhaps this suggests some underlying 'network law'. Testing the degree distribution of networks for power-law tails has been a topic of considerable discussion. statistical methodology has been used both to discredit power-laws as well as to support them.

ℓ 1-Penalized censored Gaussian graphical model.

Graphical lasso is one of the most used estimators for inferring genetic networks. Despite its diffusion, there are several fields in applied research where the limits of detection of modern measurement technologies make the use of this estimator theoretically unfounded, even when the assumption of a multivariate Gaussian distribution is satisfied. Typical examples are data generated by polymerase chain reactions and flow cytometer.

A Simple and Adaptive Dispersion Regression Model for Count Data.

Regression for count data is widely performed by models such as Poisson, negative binomial (NB) and zero-inflated regression. A challenge often faced by practitioners is the selection of the right model to take into account dispersion, which typically occurs in count datasets. It is highly desirable to have a unified model that can automatically adapt to the underlying dispersion and that can be easily implemented in practice.

Network of phosphatases and HDAC complexes at repressed chromatin.

Tight regulation of gene expression is achieved by a variety of protein complexes that selectively bind chromatin, modify it and change its transcription competency. Histone acetylases (HATs) and deacetylases (HDACs) play an important role in this process. They can generate transcriptionally active or inactive chromatin through the addition (HATs) or removal (HDACs) of acetyl groups on histones, respectively.