Publications by authors named "V Vazquez"
This study aimed to verify whether germline single nucleotide variants (SNV) in gene, c.-1765C>T, c.-1661A>G, c.
View Article and Find Full Text PDFMental health problems during childhood are associated with lowered educational attainment in adulthood. However, it is not clear if these associations hold when controlling for unobserved features of the family environment and if they depend on the socioeconomic status (SES) of parents. We use the Panel Study of Income Dynamics (PSID) Child Development and Transition into Adulthood Supplements (CDS; TAS) to examine these questions.
View Article and Find Full Text PDFArticle Synopsis
- Lysosome positioning is essential for their functions and is influenced by amino acids, which can affect cell behavior, especially in cancer cells.
- In an analysis of 15 different amino acids, 10 were found to move lysosomes toward the cell edge, particularly aromatic amino acids, through specific transport mechanisms.
- The study also revealed that while some amino acids promoted lysosome movement, they didn’t activate the mTOR signaling pathway unless combined with others, and this effect was lessened in breast cancer cells when lysosomes couldn’t reach the cell periphery.
Article Synopsis
- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with low survival rates, primarily treated through surgery and radiation, as highlighted by the Brazilian Society of Surgical Oncology's guidelines on its management.
- - The consensus emphasizes the importance of comprehensive staging, including imaging techniques like PET or CT scans, and recommends that all potential MCC cases be evaluated by a multidisciplinary team, including discussions in tumor boards to prevent treatment delays.
- - For early-stage patients (clinical stage I or II), local excision and sentinel lymph node biopsy are advised, while those with positive lymph nodes should receive radiation therapy, and advanced cases should consider participation in clinical trials for treatment options.
Article Synopsis
- Regulatory T lymphocytes help regulate the immune system and are involved in eliminating abnormal cells, particularly in the context of tumors.
- The study investigated how specific genetic variants (c.587T>G, c.*188A>G, c.*215C>T, and c.*922C>T) impact the clinical characteristics and survival of patients with cutaneous melanoma (CM).
- Results showed that certain genotypes significantly increased the risk of tumor progression and mortality, while the identified variants can be considered independent prognostic factors for CM patients.