Publications by authors named "V Vardanega"

Article Synopsis
  • Heavily treatment-experienced individuals with HIV often face limited options due to multidrug resistance, and lenacapavir (LEN) is a new treatment approved for this group in combination with other antiretrovirals.
  • A study aimed to assess the cost-effectiveness of LEN combined with an optimized background regimen compared to other recent treatments, fostemsavir (FTR) and ibalizumab (IBA), specifically for multidrug-resistant HIV cases.
  • The findings indicated that LEN+OBR provided the highest quality-adjusted life years (QALYs) and life years (LYs) over a lifetime, suggesting it may be the most effective and cost-effective option among the treatments analyzed.
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Background: UNAIDS 90-90-90 goals for HIV have been surpassed in the UK, with focus now moving to ending transmission by 2030. The concept of zero transmission is complex and many factors can influence transmission. We aimed to investigate how the target of zero transmission might be reached in the UK.

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Objectives: Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric condition, with diagnosed patients typically experiencing moderate or severe symptoms. This study evaluated the cost-of-illness (CoI) of OCD in the UK, capturing the annual costs accrued to the National Health Service (NHS) and Personal Social Services (PSS), people with OCD, caregivers and society.

Methods: The UK OCD population was estimated and stratified by age group (children, adults, elderly), symptom severity (mild, moderate, severe) and treatment received (including no treatment).

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Peristomal skin complications (PSCs) have a significant impact on quality of life and ostomy treatment costs. This study aimed to assess the healthcare resource use for patients with an ileostomy and PSCs symptoms. Two surveys were developed and, after validation by healthcare professionals and patients, data were collected on healthcare resource use while not experiencing any PSCs symptoms and while experiencing complications of various severities, as defined by the modified Ostomy Skin Tool.

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