Speech tempo in Hungarian speaking children and adolescents: The effects of age and speaking tasks.

This paper provides new data on speech tempo in typically developing Hungarian-speaking children and adolescents obtained in three different speaking contexts and analyzed using an extended set of temporal measures. We asked whether the expected developmental trend across four age levels (6, 9, 13, and 17 years) was equally reflected in children's speech rate, articulation rate, and pausing (frequency, duration, and proportion of pauses), and how their speech tempo was modulated by the cognitive demands of different speaking tasks (spontaneous narratives, story retellings, and story generations). We found a systematic incremental increase in speech rate and articulation rate with each higher age level, but the corresponding decrease in the frequency, duration, and proportion of pauses was less systematic.

Epidemiologic aspects of shoulder dystocia-related neurological birth injuries.

Purpose: The first part of the study involved data collection for the detection of geographic variations and chronologic fluctuations in the rates of shoulder dystocia. The second part of the research evaluated head-to-body delivery times in cases of arrest of the shoulders at birth that had resulted in fetal damage during the last four decades in the USA.

Methods: The study of geographic and chronologic changes in the rates of shoulder dystocia rested on reported statistics coming from the USA and 11 other countries.

Genetic variation in ALCAM and other chromosomal instability genes in breast cancer survival.

Chromosomal instability is a hallmark of many cancers and it has a potential to predict clinical outcome of a cancer patient. We hypothesized that genes whose expression status differs between chromosomal stable and unstable breast tumors represent target genes for the identification of genetic variants predicting breast cancer (BC) risk, disease progression, and survival. We used a published list of 38 genes associated with chromosomal instability as a basis for searching potentially functional and informative tagging single nucleotide polymorphisms (SNPs).

Genetic variation in genes encoding for polymerase ζ subunits associates with breast cancer risk, tumour characteristics and survival.

Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome.

Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis.

Telomeres are essential structures for maintaining chromosomal stability and their length has been reported to correlate with cancer risk and clinical outcome. Single nucleotide polymorphisms (SNPs) in genes encoding telomere-associated proteins could affect telomere length and chromosomal stability by influencing gene expression or protein configuration in the telomeres. Here, we report the results of the first association study on genetic variation in telomere-associated genes and their effect on telomere length, breast cancer (BC) susceptibility and prognosis.