[Hepatic cell transformation changes in experimental opisthorchiasis].

Changes in the liver where Opisthorchis felines (Rivolta, 1884) parasitizes were traced by light and transmission electron microscopies on experimental models (gold hamsters) of acute and chronic opisthorchiasis. Regenerative processes, such as hepatic epithelial mitotic indices, binucleated, hypertrophic hepatocytes, were determined; the composition of infiltrates was identified; fibroplastic changes and hepatocytic apoptotic index were traced. The progression/regression (P/R) ratio was used to detect atrophy of a hepatic parenchymatous component (hepatocytes) in different periods (from 3 to 120 days) of invasion.

[Prophylactics of complications of operations on the colon (experimental-clinical investigation)].

One of important aspects influencing the results of surgical treatment of patients with diseases of the colon is thought to be stepwise diagnostic and treatment measures. A retrospective analysis of treatment of 171 patients with pathology of the colon has been made. A medical-diagnostic algorithm has been developed and introduced which allowed improvement of effectiveness of medical aid in the group under study.

Morphometric analysis of the lymph system in rat heart during myocardial infarction.

Simulation of myocardial infarction in random-bred rats showed that lymph vessels play the leading role in the drainage of the myocardium during the acute period of ischemic damage and compensate for the developing insufficiency of interstitial drainage at the expense of venous component of the coronary bed. A pronounced enlargement of the lymph collectors and I, II, and order III vessels in the left and right ventricles of the heart was detected.

[The decreased susceptibility of Syrian hamsters to Opisthorchis felineus invasion after its repeated administration].

The investigations conducted on Syrian hamsters have revealed that multiple enteral infusions of cold inactivated (t = -10 degrees C) O. felineus metacercariae resulted in the formation of immunocompetent cell and fibroblast infiltrations around the branches of the portal vein. The infestation of animals by viable pathogens led to reduced accommodation of helminths and suppressed cell infiltration in the liver.

[The use of siliceous immunosorbents in hemosorption].

Experiments were conducted on rabbits and monkeys for approbation of immunosorbents by covalent immobilization of human serum albumin or antibodies to human apoprotein B on the surface of silo-chromium and subsequent incubation with 1% albumin solution. Extracorporeal immunosorption in immunized rabbits led to reduction of the level of specific antibodies by 60% and the number of blood platelets by 10-30%. The initial antibody level was restored in 5-10 days.